Zobrazeno 1 - 9
of 9
pro vyhledávání: '"J. Alan Diehl"'
Autor:
J. Nathaniel Diehl, Zhaorui Lian, Kurt D'Andrea, Katherine L. Nathanson, Weiqi Sheng, Eric K. Lee, Ravi Amaravaradi, Shujing Liu, Meenhard Herlyn, Lynn M. Schuchter, Xiaowei Xu, J. Alan Diehl, Dariusz Pytel, Olena Barbash, Richard Letrero
Publikováno v:
Molecular and Cellular Biology. 33:4422-4433
Cyclin D1-cyclin-dependent kinase 4/6 (CDK4/6) dysregulation is a major contributor to melanomagenesis. Clinical evidence has revealed that p16(INK4A), an allosteric inhibitor of CDK4/6, is inactivated in over half of human melanomas, and numerous an
Autor:
Priya Aggarwal, Craig H. Bassing, J. Alan Diehl, Olena Barbash, Laura L. Pontano, Eric J. Brown
Publikováno v:
Molecular and Cellular Biology. 28:7245-7258
While mitogenic induction of cyclin D1 contributes to cell cycle progression, ubiquitin-mediated proteolysis buffers this accumulation and prevents aberrant proliferation. Because the failure to degrade cyclin D1 during S-phase triggers DNA rereplica
Autor:
Randal J. Kaufman, Edward Arvisais, Sara B. Cullinan, Mark Hannink, Donna D. Zhang, J. Alan Diehl
Publikováno v:
Molecular and Cellular Biology. 23:7198-7209
Activation of PERK following the accumulation of unfolded proteins in the endoplasmic reticulum (ER) promotes translation inhibition and cell cycle arrest. PERK function is essential for cell survival following exposure of cells to ER stress, but the
Publikováno v:
Molecular and Cellular Biology. 23:1764-1774
The cyclin D-dependent kinase is a critical mediator of mitogen-dependent G1 phase progression in mammalian cells. Given the high incidence of cyclin D1 overexpression in human neoplasias, the nature and complexity of cyclin D complexes in vivo have
Autor:
Daniel J. Sartori, Yan Gao, Qian-Chun Yu, Jake A. Kushner, J. Alan Diehl, M. Celeste Simon, Changhong Li
Publikováno v:
Molecular and cellular biology. 32(24)
Germ line PERK mutations are associated with diabetes mellitus and growth retardation in both rodents and humans. In contrast, late embryonic excision of PERK permits islet development and was found to prevent onset of diabetes, suggesting that PERK
Autor:
Ekaterina Bobrovnikova-Marjon, Matthew J. Riese, Dariusz Pytel, Eric S. Witze, Laura Pontano Vaites, Gary A. Koretzky, J. Alan Diehl, Nickpreet Singh
Publikováno v:
Molecular and cellular biology. 32(12)
The endoplasmic reticulum (ER) resident PKR-like kinase (PERK) is necessary for Akt activation in response to ER stress. We demonstrate that PERK harbors intrinsic lipid kinase, favoring diacylglycerol (DAG) as a substrate and generating phosphatidic
Autor:
Alvaro Avivar-Valderas, Chandandeep Nagi, Jayanta Debnath, Eduardo Salas, J. Alan Diehl, Julio A. Aguirre-Ghiso, Ekaterina Bobrovnikova-Marjon
Publikováno v:
Molecular and cellular biology. 31(17)
Mammary epithelial cells (MECs) detached from the extracellular matrix (ECM) produce deleterious reactive oxygen species (ROS) and induce autophagy to survive. The coordination of such opposing responses likely dictates whether epithelial cells survi
Publikováno v:
Molecular and Cellular Biology. 13:1769-1778
Autor:
Ying-Yu Chen, John J. Welch, Mitchell J. Weiss, J. Alan Diehl, Marcin Rylski, Danielle L. Letting, Gerd A. Blobel, Lewis A. Chodosh
Publikováno v:
Molecular and cellular biology. 23(14)
Transcription factor GATA-1 is essential for erythroid and megakaryocytic maturation. GATA-1 mutations are associated with hematopoietic precursor proliferation and leukemogenesis, suggesting a role in cell cycle control. While numerous GATA-1 target