Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Thomas H"'
Autor:
Lawrence A. Loeb, Piper M. Treuting, Ted Gooley, Bradley D. Preston, Ranga N. Venkatesan, Warren C. Ladiges, Evan D. Fuller, Thomas H. Norwood, Robert E. Goldsby
Publikováno v:
Molecular and Cellular Biology. 27:7669-7682
Eukaryotic DNA polymerase δ (Pol δ) is an essential, highly conserved enzyme that participates in DNA replication, DNA repair, and genetic recombination. Pol δ is believed to replicate a large portion of the genome, synthesizing most of the laggin
Autor:
Niels Behrendt, Julie Gavard, Kenn Holmbeck, Susan S. Yamada, Lars H. Engelholm, J. Silvio Gutkind, Thomas H. Bugge, Rebecca A. Wagenaar-Miller
Publikováno v:
Molecular and Cellular Biology. 27:6309-6322
Collagen degradation is essential for cell migration, proliferation, and differentiation. Two key turnover pathways have been described for collagen: intracellular cathepsin-mediated degradation and pericellular collagenase-mediated degradation. Howe
Autor:
Junqiang Ye, Thomas H. Eickbush
Publikováno v:
Molecular and Cellular Biology. 26:8781-8790
About half of the rRNA gene units (rDNA units) of Drosophila melanogaster are inserted by the retrotransposable elements R1 and R2. Because transcripts to R1 and R2 were difficult to detect on blots and electron microscopic observations of rRNA synth
Publikováno v:
Molecular and Cellular Biology. 25:6617-6628
R2 elements are non-long terminal repeat retrotransposons that specifically insert into 28S rRNA genes of many animal groups. These elements encode a single protein with reverse transcriptase and endonuclease activities as well as specific DNA and RN
Autor:
Thomas H. Giddings, Mark Winey, Cornelia Kurischko, Manali Mody, David M. Roof, Francis C. Luca
Publikováno v:
Molecular and Cellular Biology. 21:6972-6983
The Saccharomyces cerevisiae mitotic exit network (MEN) is a conserved set of genes that mediate the transition from mitosis to G(1) by regulating mitotic cyclin degradation and the inactivation of cyclin-dependent kinase (CDK). Here, we demonstrate
Publikováno v:
Molecular and Cellular Biology. 19:7461-7472
In budding yeast (Saccharomyces cerevisiae), the majority of box H/ACA small nucleolar RNPs (snoRNPs) have been shown to direct site-specific pseudouridylation of rRNA. Among the known protein components of H/ACA snoRNPs, the essential nucleolar prot
Autor:
Jin Yang, Thomas H. Eickbush
Publikováno v:
Molecular and Cellular Biology. 18:3455-3465
R2 is a non-long terminal repeat retrotransposable element that inserts itself site specifically in the 28S rRNA genes of arthropods. The 120-kDa protein encoded by R2 has been shown to cleave one strand of the 28S gene at the target site and to use
Autor:
Danna G. Eickbush, Thomas H. Eickbush
Publikováno v:
Molecular and cellular biology. 30(13)
The non-long terminal repeat (non-LTR) retrotransposon R2 is inserted into the 28S rRNA genes of many animals. Expression of the element appears to be by cotranscription with the rRNA gene unit. We show here that processing of the rRNA cotranscript a
Publikováno v:
Molecular and cellular biology. 28(20)
R2 retrotransposable elements exclusively insert into a conserved region of the tandemly organized 28S rRNA genes. Despite inactivating a subset of these genes, R2 elements have persisted in the ribosomal DNA (rDNA) loci of insects for hundreds of mi
Autor:
Danna G. Eickbush, Thomas H. Eickbush
Publikováno v:
Molecular and cellular biology. 23(11)
R2 retrotransposons insert into the rRNA-encoding units (rDNA units) that form the nucleoli of insects. We have utilized an R2 integration system in Drosophila melanogaster to study transcription of foreign sequences integrated into the R2 target sit