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Autor:
Manu Verma, Nellie Y. Loh, Rugivan Sabaratnam, Senthil K. Vasan, Andrea D. van Dam, Marijana Todorčević, Matthew J. Neville, Enrique Toledo, Fredrik Karpe, Constantinos Christodoulides
Publikováno v:
Metabolism. 133:155240
Introduction Non-coding genetic variation at TCF7L2 is the strongest genetic determinant of type 2 diabetes (T2D) risk in humans. TCF7L2 encodes a transcription factor mediating the nuclear effects of WNT signaling in adipose tissue (AT). In vivo stu