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Publikováno v:
mAbs
Biotherapeutic proteins are commonly dosed at high concentrations into the blood, which is an inherently complex, crowded solution with substantial protein content. The effects of macromolecular crowding may lead to an appreciable level of non-specif
Autor:
Feng Li, Zhidan Wu, Jin Chen, Huang Sijia, Zhang Boyan, Xinqiu Yuan, Jiannan Feng, Chunyang Jin, Xiaochuan Fan, Huifang Liu, Beifen Shen, Ye Pei
Publikováno v:
mAbs. 10:864-875
MBS301, a glyco-engineered bispecific anti-human epidermal growth factor receptor 2 (HER2) antibody with a typical IgG1 monoclonal antibody structure, was developed through dual-cell expression and in vitro assembling process. MBS301 consists of two
Autor:
Aurélie Terrier, Emilie Jacque, Delphine Derache, Alexandre Fontayne, Aurélie Dehenne, Cécile Beghin, Alain Longue, Christophe De Romeuf, Gilles Dupont, Linda Baptista, Virginie Pochet-Beghin, Sami Chtourou, Anne-Sophie Dezetter, Nathalie Fournier, Lucie Verhaeghe
Publikováno v:
mAbs
Plasmacytoid dendritic cells (pDCs) play a central role for both innate and adaptive antiviral responses, as they direct immune responses through their unique ability to produce substantial concentrations of type I interferon (IFNs) upon viral encoun
Publikováno v:
mAbs
During the development of monoclonal antibodies (mAbs) and other therapeutic proteins, immunogenicity, in particular the induction of anti-drug antibodies (ADAs), is an important concern, and thus immunogenicity assessment is a requirement for their
Autor:
Steven M Vicik, Morton Scheinberg, Uppuluri R K Rao, Brian Fitzpatrick, Julie O'Brien, Ena Singh, Mengtao Li, Ehab Mahgoub, Javier Coindreau, Brian Hassett, Gilberto Castañeda-Hernández
Publikováno v:
mAbs. 10:166-176
Fusion protein and monoclonal antibody-based tumor necrosis factor (TNF) inhibitors represent established treatment options for a range of inflammatory diseases. Regulatory authorities have outlined the structural characterization and clinical assess
Publikováno v:
mAbs. 9:1155-1168
Preferential interactions of weakly interacting formulation excipients govern their effect on the equilibrium and kinetics of several reactions of protein molecules in solution. Using vapor pressure osmometry, we characterized the preferential intera
Autor:
Tiansheng Li, Yang Liu, Yanchun Ma, Meng Li, Lina Sun, Mifang Liang, Chuan Li, Li Chen, Lei Wang, Jisu Li, Shuping Tong, Wei Wang, Youhua Xie, Yumei Wen
Publikováno v:
mAbs. 8:468-477
Hepatitis B virus (HBV) produces large (L), middle (M), and small (S) envelope proteins, alternatively referred to as hepatitis B surface antigen (HBsAg). Currently, yeast-derived S protein serves as the preventive vaccine, while hepatitis B immune g
Publikováno v:
mAbs. 8:99-112
The aggregation of biotherapeutics is a major hindrance to the development of successful drug candidates; however, the propensity to aggregate is often identified too late in the development phase to permit modification to the protein's sequence. Inc