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Autor:
Zhonghua Xu, Chang Chen, Yongbing Chen, Yongsheng Zhang, Junmiao Wen, Donglai Chen, Xiaofan Wang, Qifeng Ding
Publikováno v:
Lung cancer (Amsterdam, Netherlands). 134
To further investigate the relationship between the cribriform component and spread through air spaces (STAS), and to unravel the potential pathological mechanism of poor prognoses in lung adenocarcinoma (LUAD) patients with a cribriform component.We
Autor:
Masahiro Tsuboi, Tomohiro Ichikawa, Keiju Aokage, Kenji Suzuki, Tomohiro Miyoshi, Genichiro Ishii, Hideki Makinoshima, Kenta Tane
Publikováno v:
Lung cancer (Amsterdam, Netherlands). 136
The purpose of this study was to investigate whether fluorodeoxyglucose (FDG) accumulation is associated with the expression of microenvironmental factors in radiological pure-solid lung adenocarcinoma.We selected 50 cases involving patients with cli
Paired genomic analysis of squamous cell carcinoma transformed from EGFR-mutated lung adenocarcinoma
Autor:
Youjin Kim, Boram Lee, Sehhoon Park, Jong-Mu Sun, Keunchil Park, Joon Ho Shim, Jin Seok Ahn, Woong-Yang Park, Se-Hoon Lee, Inju Cho, Yoon-La Choi, Myung-Ju Ahn, Joungho Han
Publikováno v:
Lung cancer (Amsterdam, Netherlands). 134
Objectives Adenocarcinoma (ADC) to squamous cell carcinoma (SCC) transformation (AST) is reported in epidermal growth factor receptor (EGFR)-mutated non–small cell lung cancer after tyrosine kinase inhibitor (TKI) failure. However, little is known
Autor:
Akira Iyoda, Satoshi Fujii, Motohiro Kojima, Takashi Sakai, Masato Sugano, Takeshi Kuwata, Shinya Neri, Hiroshi Nakamura, Kenta Tane, Tomohiro Miyoshi, Keiju Aokage, Shogo Nomura, Masahiro Tsuboi, Atsushi Ochiai, Genichiro Ishii
Publikováno v:
Lung cancer (Amsterdam, Netherlands). 126
Podoplanin-positive cancer-associated fibroblasts [PDPN (+) CAFs] play an important role in cancer progression in non-small-cell lung cancer. The aim of this study was to clarify the correlation between a fibrous microenvironment containing PDPN (+)
Autor:
Kerr, Keith M, Thunnissen, Erik, Dafni, Urania, Finn, Stephen P, Bubendorf, Lukas, Soltemiann, Alex, Verbeken, Eric, Biernat, Wojciech, Warth, Arne, Marchetti, Antonio, Speel, Ernst-Jan M, Pokharel, Sarawati, Quinn, Anne Marie, Monlchorst, Kim, Navarro, Atilio, Madsen, Line Bille, Radonic, Teodora, Wilson, Joan, De Luca, Graziano, Gray, Steven G, Cheney, Richard, Savic, Spasenija, Martorell, Miguel, Muley, Thomas, Baas, Paul, Meldgaard, Peter, Blackhall, Fiona, Dingemans, Anne-Marie, Dziadziuszko, Rafal, Vansteenkiste, Johan, Weder, Walter, Polydoropoulou, Varvara, Geiger, Thomas, Kammler, Roswitha, Peters, Solange, Stahel, Rolf, Rosell, Rafael, Molina, Miguel Angel, Hiltbrunner, Anita, Marti, Nesa, Tsourti, Zoi, Zygoura, Panagiota, Nicolson, Marianne, Stevenson, David AJ, Mathieson, William, Smit, Egbert, van Setten, Coralien, Soltermann, Alex, Rulle, Undine, Curioni, Alessandra, Mc Fadden, Julie, Cuffe, Sinead, Lardinois, Didier, Nackaerts, Kristiaan, Dooms, Christophe, Wauters, Els, Van Der Borght, Sara, Wrona, Ania, Rzyman, Witold, Jassem, Jacek, Dienemann, Hendrik, di Lorito, Alessia, Ruland, Andrea, Ferenczy, Philip, Franklin, Lynsey, Monkhorst, Kim, van de Wiel, Bart, Camps, Carlos
Publikováno v:
Kerr, K M, Thunnissen, E, Dafni, U, Finn, S P, Bubendorf, L, Soltermann, A, Verbeken, E, Biernat, W, Warth, A, Marchetti, A, Speel, E J M, Pokharel, S, Quinn, A M, Monkhorst, K, Navarro, A, Madsen, L B, Radonic, T, Wilson, J, De Luca, G, Gray, S G, Cheney, R, Savic, S, Martorell, M, Muley, T, Baas, P, Meldgaard, P, Blackhall, F, Dingemans, A M, Dziadziuszko, R, Vansteenkiste, J, Weder, W, Polydoropoulou, V, Geiger, T, Kammler, R, Peters, S, Stahel, R & for the Lungscape Consortium 2019, ' A retrospective cohort study of PD-L1 prevalence, molecular associations and clinical outcomes in patients with NSCLC : Results from the European Thoracic Oncology Platform (ETOP) Lungscape Project ', Lung Cancer, vol. 131, pp. 95-103 . https://doi.org/10.1016/j.lungcan.2019.03.012
Lung Cancer, 131, 95-103. Elsevier Ireland Ltd
Kerr, K M, Thunnissen, E, Dafni, U, Finn, S P, Bubendorf, L, Soltermann, A, Verbeken, E, Biernat, W, Warth, A, Marchetti, A, Speel, E-J M, Pokharel, S, Quinn, A M, Monkhorst, K, Navarro, A, Madsen, L B, Radonic, T, Wilson, J, de Luca, G, Gray, S G, Cheney, R, Savic, S, Martorell, M, Muley, T, Baas, P, Meldgaard, P, Blackhall, F, Dingemans, A-M, Dziadziuszko, R, Vansteenkiste, J, Weder, W, Polydoropoulou, V, Geiger, T, Kammler, R, Peters, S, Stahel, R & Lungscape Consortium 2019, ' A retrospective cohort study of PD-L1 prevalence, molecular associations and clinical outcomes in patients with NSCLC: Results from the European Thoracic Oncology Platform (ETOP) Lungscape Project ', Lung Cancer, vol. 131, pp. 95-103 . https://doi.org/10.1016/j.lungcan.2019.03.012
Lung Cancer, 131, 95-103. Elsevier Ireland Ltd
Kerr, K M, Thunnissen, E, Dafni, U, Finn, S P, Bubendorf, L, Soltermann, A, Verbeken, E, Biernat, W, Warth, A, Marchetti, A, Speel, E-J M, Pokharel, S, Quinn, A M, Monkhorst, K, Navarro, A, Madsen, L B, Radonic, T, Wilson, J, de Luca, G, Gray, S G, Cheney, R, Savic, S, Martorell, M, Muley, T, Baas, P, Meldgaard, P, Blackhall, F, Dingemans, A-M, Dziadziuszko, R, Vansteenkiste, J, Weder, W, Polydoropoulou, V, Geiger, T, Kammler, R, Peters, S, Stahel, R & Lungscape Consortium 2019, ' A retrospective cohort study of PD-L1 prevalence, molecular associations and clinical outcomes in patients with NSCLC: Results from the European Thoracic Oncology Platform (ETOP) Lungscape Project ', Lung Cancer, vol. 131, pp. 95-103 . https://doi.org/10.1016/j.lungcan.2019.03.012
INTRODUCTION: The PD-L1 biomarker is an important factor in selecting patients with non-small cell lung cancer for immunotherapy. While several reports suggest that PD-L1 positivity is linked to a poor prognosis, others suggest that PD-L1 positive st
Autor:
Yohei Takumi, Takafumi Hashimoto, Michiyo Miyawaki, Atsushi Osoegawa, Hideya Takeuchi, Tatsuro Okamoto, Miyuki Abe, Ryoji Kobayashi, Kenji Sugio
Publikováno v:
Lung cancer (Amsterdam, Netherlands). 124
Background Although intratumoral heterogeneity is commonly observed in several cancers, few studies have shown its presence in EGFR-mutated lung cancer. We performed immunohistochemistry to analyze the intratumoral heterogeneity in EGFR-mutated (L858
Autor:
Takashi Kohno, Hiroshi Nanjo, Zhuo Li, Makoto Yoshida, Yoshihiro Minamiya, Hajime Saito, Motonobu Saito, Michinobu Umakoshi, Kouya Shiraishi, Hayato Konno, Daichi Maeda, Akiteru Goto
Publikováno v:
Lung cancer (Amsterdam, Netherlands). 123
Tumor-associated macrophages (TAMs) are believed to influence tumor progression and the prognosis of patients. The purpose of this study was to clarify the correlation between the TAM density or location and the clinicopathological features of non-sm
Autor:
T. Montella, Fabiane Carvalho de Macedo, Pedro Masson Domingues, Veronica Aran, Carlos Gil Ferreira, Carlos Augusto Moreira de Sousa, Maria Theresa de Souza Accioly
Publikováno v:
Lung cancer (Amsterdam, Netherlands). 116
Objectives Mammalian cells differently express 4 RAS isoforms: H-RAS, N-RAS, K-RAS4A and K-RAS4B, which are important in promoting oncogenic processes when mutated. In lung cancer, the K-RAS isoform is the most frequently altered RAS protein, being a
Autor:
Matthew D. Hellmann, Ai Ni, Sutirtha Datta, William D. Travis, Linda Ahn, Juliana Schilsky, N. Rekhtman, Mark G. Kris, Jamie E. Chaft
Publikováno v:
Lung cancer (Amsterdam, Netherlands). 108
OBJECTIVES: Thyroid transcription factor 1 (TTF-1) is routinely tested in the diagnostic evaluation of suspected lung cancers, is commonly expressed by lung adenocarcinomas, and may modulate lung cancer biology. We examined the role of TTF-1 as a pre
Autor:
Mohamed Feroz Mohd Omar, Grace Sia, Zul Fazreen, Byoung Chul Cho, Hye Ryun Kim, Bernadette Reyna Asuncion, Maria Cynthia Herrera, Richie Soong, Ross A. Soo, Joey Sze Yun Lim
Publikováno v:
Lung cancer (Amsterdam, Netherlands). 105
Objectives To characterize the expression of PD-L1, PD-1, cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and T-cell immunoglobulin and mucin-domain containing-3 (TIM3) in epidermal growth factor receptor ( EGFR ) mutant non-small cell lung canc