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Efficacy of immune check-point inhibitors (ICPi) in large cell neuroendocrine tumors of lung (LCNEC)
Publikováno v:
Lung Cancer. 143:40-46
Objectives Little is known regarding the ICPi efficacy in LCNEC. We explored the efficacy and safety of ICPi in LCNEC and assessed its impact on OS. Materials and methods Thirty-seven consecutive patients with advanced LCNEC were selected from the Da
Autor:
Ron Pritzkuleit, Bernd Holleczek, Gundula Behrens, Lina Jansen, Lars Schwettmann, Michael Gerken, Isabelle Finke, Hermann Brenner
Publikováno v:
Lung Cancer 142, 1-8 (2020)
Publons
Publons
Objectives Studies from several countries reported socioeconomic inequalities in lung cancer survival. Hypothesized reasons are differences in cancer care or tumor characteristics. We investigated associations of small-area deprivation and lung cance
Autor:
Anas Gazzah, Pilar Garrido, Alexis B. Cortot, Jaafar Bennouna, Melissa Lynne Johnson, Maciej Gil, Haruyasu Murakami, Benjamin Besse
Publikováno v:
Lung Cancer. 142:63-69
Objectives Efficacy and safety of necitumumab when combined with pembrolizumab was assessed in patients with Stage IV non-small cell lung cancer (NSCLC) of squamous and nonsquamous histology, who had progressed after treatment with a platinum-based d
Autor:
Patrick Leo, Pranjal Vaidya, Kaustav Bera, Rajat Thawani, Michael Feldman, Mehdi Alilou, Prabhakar Rajiah, Philip A. Linden, Robert C. Gilkeson, Pingfu Fu, Harvey I. Pass, Mohammadhadi Khorrami, Pradnya D. Patil, Vamsidhar Velcheti, Priya Velu, Humberto Choi, Anant Madabhushi
Publikováno v:
Lung Cancer
Objectives To evaluate whether combining stability and discriminability criteria in building radiomic classifiers will improve the prognosis of cancer recurrence in early stage non-small cell lung cancer on non-contrast computer tomography (CT). Mate
Autor:
Amy T.Y. Chang, Tony Mok, Frankie Mo, Jacky Y.C. Li, Oscar S.H. Chan, Ki Wang, Catherine Y.H. Wong, Rebecca M.W. Yeung, Kwok Chi Lam, Frankie P. T. Choi
Publikováno v:
Lung Cancer. 142:41-46
Objectives NSCLC patients harboring EGFR mutation invariably developed resistance to EGFR TKI. We postulated that oligoresidual disease (ORD) after initial TKI might harbor resistant clones. This study aimed to test if preemptive local ablative thera
Autor:
Kazuya Shinmura, Yuji Iwashita, Masayuki Tanahashi, Kazuhito Funai, Haruhiko Sugimura, Takafumi Suda, Katsuhiro Yoshimura, Naoki Inui, Hiroshi Niwa, Masato Karayama, Hidetaka Yamada, Akikazu Kawase, Yusuke Inoue, Hiroshi Ogawa, Kazuo Tsuchiya
Publikováno v:
Lung Cancer. 141:21-31
Alterations in the MET gene, such as mutations and high-level amplification, are important drivers of non-small cell lung cancer (NSCLC). The efficacy of immune checkpoint inhibitors (ICIs) in lung cancer with MET abnormalities is unclear. We evaluat
Autor:
Takashi Seto, Noboru Yamamoto, Takeharu Yamanaka, Yuichiro Ohe, Makoto Nishio, Tatsuya Yoshida, Toyoaki Hida, Akira Ono, Takayasu Kurata, Kentaro Sakamaki, Hiroaki Okamoto, Miyako Satouchi, Seiji Niho, Koichi Goto, Tetsuo Akimoto
Publikováno v:
Lung Cancer. 141:64-71
Objectives SPECTRA is a multicenter, randomized phase II study of chemotherapy with cisplatin (CDDP) plus S-1 versus CDDP plus pemetrexed (PEM) in combination with thoracic radiotherapy (TRT) for locally advanced non-squamous non-small cell lung canc
Autor:
Jacob Sands, Geoffrey R. Oxnard, Pasi A. Jänne, Frank C. Kuo, Adrian G. Sacher, Tom C. Nguyen, Lynette M. Sholl, Michael Cheng, Priyanka Shivdasani, Ryan S. Alden
Publikováno v:
Lung Cancer. 140:35-41
Objectives Potentially targetable genomic alterations have been identified in lung squamous cell carcinoma (LUSC), but none have yet translated into effective therapy. We examined potential benefits of next generation sequencing (NGS) in a cohort of
Autor:
Horiana B. Grosu, David Ost, Graciela Noguras Gonzalez, Andrea Manzanera, Sudeep Shivakumar, Simon Sun
Publikováno v:
Lung Cancer. 140:55-58
Clinical decisions for NSCLC patients are often based on TNM stage, which does not account for different histological subtype. Whether histological subtype affects survival still remains unclear. The main objective of this study was to determine the
Autor:
Min Chen, Haijun Wu, Dan Shao, Lei Shi, Qing Zhang, Song Dong, Xiaoyu Huang, Yan Cao, Minn Thant, Xiuhui Li
Publikováno v:
Lung Cancer. 140:80-86
Objective To determine the clinical value of 18F-FDG-PET/CT and dual-energy virtual noncalcium CT to detect and identify single osteolytic metastases (SOM) in participants with non-small cell lung cancer (NSCLC). Materials and Methods Forty-two parti