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Publikováno v:
Life Sciences. 50:PL149-PL154
The paper describes the effects of various regimens of lithium chloride treatment on dexamethasone-induced increases in brain polyamine metabolizing enzymes. In contrast to peripheral tissues where acute lithium treatment suppresses the increase in o
Autor:
Stephen G. Holtzman
Publikováno v:
Life Sciences. 49:1563-1570
CGS 15943 (0.1–10 mg/kg, IP) dose-dependently increased the locomotor activity of rats to the same extent as caffeine (1.0–100 mg/kg, IP) did and was approximately 26 times more potent than caffeine. N-Ethylcarboxamidoadenosine (0.001–0.01 mg/k
Autor:
Dorotea Muck-Seler, Danka Peričić
Publikováno v:
Life Sciences. 46:1331-1342
The mechanisms by which imipramine and dihydroergosine stimulate the 5-HT syndrome in rats and inhibit the head-twitch response in rats and mice were studied. Imipramine- and dihydroergosine-induced stimulation of the 5-HT syndrome was inhibited ster
Autor:
Linda Band, Nigel H. Greig, Kenner C. Rice, Heng Xu, Richard B. Rothman, Amy Hauck Newman, Victor Bykov, Arthur E. Jacobson, Chong-Ho Kim
Publikováno v:
Life sciences. 47(24)
The present study demonstrates that pretreatment of rat brain membranes with (+)-cis-3-methylfentanyl {(+)-cis-MF}, followed by extensive washing of the membranes, produces a wash-resistant decrease in the binding of [ 3 H]-[D-ala 2 , D-leu 5 ]enkeph
Autor:
James Welch, Susan Gerhardt, Jeffrey M. Liebman, Paul L. Wood, A.M. Wasley, C.A. Altar, H.S. Kim
Publikováno v:
Life Sciences. 39:699-705
CGS 10746B, a benzothiadiazepine, has a behavioral profile in mice and monkeys similar to the atypical antipsychotic clozapine. Unlike clozapine, CGS 10746B suppresses dopamine neuron firing rates and, when administered at behaviorally effective dose
Publikováno v:
Life Sciences. 44:1449-1455
Post-synaptic receptor modulation is thought to be one important mechanism involved in the adaptation of a neuronal system during chronic exposure to a drug. However, initial studies of opioid receptor regulation following chronic in vivo administrat
Publikováno v:
Life Sciences. 33:1127-1134
A 2.0 mg per kg oral dose of l-alpha-acetylmethadol (LAAM) administered daily to female rats prior to mating and throughout pregnancy increased ethylmorphine N-demethylase activity in liver microsomes of the dams measured 24 h after parturition. This
Autor:
Salvatore J. Enna, Andrzej Pilc
Publikováno v:
Life Sciences. 37:1183-1194
Experiments were undertaken to examine the characteristics of the adrenergic receptor-coupled cAMP system in rat brain slices. It was found that the potentiation of isoproterenol-stimulated cAMP accumulation by 6-fluoronorepinephrine, an alpha-adrene
Publikováno v:
Life sciences. 42(24)
Pirenzepine, the prototype M1 muscarinic receptor antagonist, is an important compound for investigating the functional significance of M1 receptors at the integrated level of behavior but may have limitations imposed by its physical chemistry. Like
Publikováno v:
Life sciences. 43(23)
Pupillary and cardiac responses to i.v. injections of chlordimeform (CDM, 0.3-10 mg/kg), a formamidine insecticide, and its metabolites demethylchlordimeform (DCDM, 0.03-1 mg/kg) and didemethylchlordimeform (DDCDM, 0.1-3 mg/kg) were studied in rats a