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pro vyhledávání: ''
Autor:
Ana L. Graça, Daniel C. Moura, Raquel Martinho, Mónica Moreira-Rodrigues, Paula Serrão, P. Mendes
Publikováno v:
Life Sciences. 156:1-6
Aims Epinephrine is unique among biogenic catecholamines as a potent agonist of β 2 -adrenoceptors. The β 2 -adrenoceptor mediated effects during development might be linked to the increase of epinephrine synthesis. Our purpose was to characterize
Autor:
Kazutaka Aonuma, Dongzhu Xu, Akira Sato, Tomoya Hoshi, Nobuyuki Murakoshi, Taizo Kimura, Takeshi Machino
Publikováno v:
Life sciences. 110(2):86-92
Aims We aimed to investigate the anti-hypertensive effect of radiofrequency (RF) renal denervation (RDN) in an animal model of hypertension. Materials and methods RF energy was delivered to bilateral renal arteries through a 2Fr catheter with opening
Autor:
José Cipolla-Neto, Darine Villela, Larissa de Sá Lima, Rafael Peres, Rodrigo A. Peliciari-Garcia, Fernanda Gaspar do Amaral, Cristoforo Scavone, Solange Castro Afeche
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Aims The circadian rhythm in mammalian pineal melatonin secretion is modulated by norepinephrine (NE) released at night. NE interaction with β 1 -adrenoceptors activates PKA that phosphorylates the transcription factor CREB, leading to the transcrip
Autor:
Mani Chopra, David E. Dostal, Linley E. Watson, Honey B. Golden, Avadhesh C. Sharma, Padmalaya Das
Publikováno v:
Life Sciences. 87:672-678
We examined the effect of norepinephrine (NE) infusion on left ventricular function and apoptotic genes during progression of polymicrobial sepsis.Male Sprague-Dawley rats (350-400 g) were made septic by intraperitoneal (i.p.) administration of 200mg
Autor:
Jéssica Aparecida da Silva, Fernanda Gaspar do Amaral, José Cipolla-Neto, Solange Castro Afeche, Anderson Carlos Marçal, Daniella Carmo-Buonfiglio, Carla Roberta de Oliveira Carvalho, Rodrigo A. Peliciari-Garcia
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Aims In our previous work, we reported that the insulin potentiating effect on melatonin synthesis is regulated by a post-transcriptional mechanism. However, the major proteins of the insulin signaling pathway (ISP) and the possible pathway component
Autor:
José Cipolla-Neto, Fábio Bessa Lima, Fernanda Gaspar do Amaral, Solange Castro Afeche, J H Scialfa, Martin E. Young, Rodrigo Antonio Peliciari Garcia, Sabrina Heloisa José dos Santos
Publikováno v:
Life Sciences. 82:108-114
The mammalian pineal gland synthesizes melatonin in a circadian manner, peaking during the dark phase. This synthesis is primarily regulated by sympathetic innervations via noradrenergic fibers, but is also modulated by many peptidergic and hormonal
Autor:
Yoshimitsu Tsuzuki, Mikito Hayashi, Yohei Yanagida, Yuko Takeba, Sachiko Nakaya, Naoki Matsumoto, Toshio Kumai, Shinichi Kobayashi
Publikováno v:
Life Sciences. 81:1193-1198
We investigated the effects of fasudil, a Rho kinase inhibitor, on hypertension in spontaneously hypertensive rats and on the catecholamine synthetic pathway. Ten-week-old male SHR and Wistar-Kyoto rats were administered fasudil (10 mg/kg/day s.c.) f
Publikováno v:
Life Sciences. 77:1381-1390
We investigated the effects of hydrocortisone during the prenatal period and its repercussion on puberty installation and adrenergic response of seminal vesicle in adult rats. The efficacy of the hydrocortisone treatment in reducing adrenal wet weigh
Autor:
A.R. Jayakumar, R. Ramakrishnan, K. Prabhakaran, Duraisamy Kempuraj, Devi Rs, A. Namasivayam, Suthanthirarajan N
Publikováno v:
Life Sciences. 77:1825-1835
Chronic diabetes is associated with the alteration of second messengers and CNS disorders. We have recently identified that protein kinases (CaMKII and PKC-alpha) and brain neurotransmitters are altered during diabetes as well as in hyperglycemic and
Publikováno v:
Life Sciences. 73:715-726
Many aspects of drug abuse and addiction share neurobiological substrates with the modulatory processes underlying the response and adaptation to acute stress. In particular, the ascending noradrenergic system has been implicated in facilitating the