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Publikováno v:
Life Sciences. 230:97-103
Aim Acetaminophen (APAP) overdose is the most frequent cause of drug-induced liver damage. Magnolia officinalis is a traditional hepatoprotective Chinese medicine and Honokiol (HO) is the major active constituent. The present study was to investigate
Autor:
Sajad Jeddi, Pedro González-Muniesa, Mahboubeh Ghanbari, Hanieh Gholami, Asghar Ghasemi, Reza Norouzirad, Mehdi Hedayati
Publikováno v:
Life Sciences. 230:188-196
Aims Hyperoxia has beneficial metabolic effects in type 2 diabetes. However, hyperoxia exacerbates already existing oxidative stress in type 2 diabetes. Nitrate, a nitric oxide donor, is an effective new treatment in type 2 diabetes and also has anti
Autor:
Walter Manucha, Luiz Gustavo de Almeida Chuffa, Russel J. Reiter, Vinícius Augusto Simão, Virna Margarita Martín Giménez
Publikováno v:
Life sciences. 288
Vascular inflammation is one of the main activating stimuli of cardiovascular disease and its uncontrolled development may worsen the progression and prognosis of these pathologies. Therefore, the search for new therapeutic options to treat this cond
Autor:
Oleg Kornushin, Elizaveta Savochkina, Yana G. Toropova, Michael M. Galagudza, Marina L. Vasyutina, Irina Zelinskaya, Vyacheslav Dyachuk
Publikováno v:
Life sciences. 286
Aims Type 2 diabetes mellitus (T2DM) ranks in the top 10 causes of mortality worldwide. The key factor of T2DM vascular complications is endothelial dysfunction. It is characterized by the vessels motor activity disruption and endothelium-derived fac
Publikováno v:
Life sciences. 285
Chemical renal toxicity is common and has limited therapeutic interventions. The NLRP3 inhibitor dapansutrile (DAPA) undergoes clinical phase II trials and it shows promising beneficial effects in various inflammatory diseases. The current study aims
Publikováno v:
Life sciences. 285
Aims Diabetes, a serious worldwide problem, is modulated via inflammation and oxidative stress. Bromelain, a natural compound, recently attracts interest due to its anti-inflammatory effects, while its mode of action remains not properly understood.
Publikováno v:
Life sciences. 286
Objective Endothelial dysfunction occurs as an early event in cardiovascular disease. Previously, vorapaxar, a proteinase-activated receptor-1 antagonist, was shown to cause endothelial damage in a cell culture study. Therefore, our study aimed to co
Autor:
Zhengdan Zhu, Peng Lei, Xingxing Diao, Mimi Wan, Yaru Xue, Dafang Zhong, Xuelian Ren, He Huang, Mengling Liu
Publikováno v:
Life sciences. 287
Aims 3-n-Butylphthalide (NBP) is widely used for the treatment of cerebral ischaemic stroke but can causeliver injury in clinical practice. This study aims to elucidate the underlying mechanisms and propose potential preventive strategies. Main metho
Autor:
Amanda Marreiro Barbosa, Henrik Ortsäter, Bryanne Silva Figueiredo, Alex Rafacho, Francielle Batista D. Ferreira, Cristiane dos Santos
Publikováno v:
Life sciences. 286
Aims Glucocorticoids (GC) in excess cause glucose intolerance and dyslipidemia due to their diabetogenic actions. Conceptually, antidiabetic drugs should attenuate these side effects. Thus, we evaluated whether the coadministration of metformin or si
Autor:
Xing Luo, Shaoyu Liu, Jianxin Huang, Bo Yu, Xiuzhu Weng, Xiaoyi Bao, Xiaoxuan Bai, Haibo Jia, Yi Feng
Publikováno v:
Life sciences. 291
Aims Pyroptosis is a pro-inflammatory form of programmed cell death, which plays a vital role in the development of inflammatory diseases. As a natural flavonoid, quercetin has been shown to possess anti-inflammatory activity, but its effects on macr