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Publikováno v:
Life sciences. 286
Objective Endothelial dysfunction occurs as an early event in cardiovascular disease. Previously, vorapaxar, a proteinase-activated receptor-1 antagonist, was shown to cause endothelial damage in a cell culture study. Therefore, our study aimed to co
Publikováno v:
Life Sci
Aims Sudden unexpected death in epilepsy (SUDEP) is a serious and underestimated public health burden. Both clinical and animal studies show that seizure-induced respiratory arrest (S-IRA) is the primary cause of death in SUDEP. Our previous studies
Autor:
Bachahalli Madappa Arpitha, Islam Johurul, Arunachalam Muthuraman, Mysore Srinivasmurthy Sowmya, Nagdol Choedon, Kamus Nafisa, Narahari Rishitha, Crasta Denis Sandy
Publikováno v:
Life Sciences. 222:133-139
Background Cigarette smoke is exogenous modifiable factors to changes the neurovascular complication. The chronic exposure of cigarette smoke enhances neurocognitive dysfunction. Aims The present study is focused on evaluating the role of ambrisentan
Publikováno v:
Life Sciences. 222:112-116
Background Due to complex pathogenesis of Alzheimer's disease (AD), currently there is no effective disease-modifying treatment. Acetylcholinesterase (AChE) has introduced itself as an important target for AD therapy. Linarin as the representative ac
Autor:
Larissa Rugila S. Stopa, Andressa Busetti Martins, Ernane Torres Uchoa, Cristiane M. Leite, Dimas A. M. Zaia, Marcela Cristina Garnica-Siqueira, Cássia T. B. V. Zaia, Fabio Andrade, Leticia Correa N. Takasumi, Geisielle Fernandes Santos, Camila F. de Souza, Renan Nascimento Ferreira
Publikováno v:
Life Sciences. 218:185-196
Glucocorticoids increase appetite and body weight gain in rats and ovariectomy (OVX) induces obesity, while estrogen (E) replacement attenuates OVX-induced changes. It is known that animals with obesity are more responsive to glucocorticoids anabolic
Publikováno v:
Life Sciences. 218:274-283
Aims The tyrosine kinase inhibitor imatinib has been used in prostate cancer treatment with outcomes that did not follow the in vitro findings. The glycolytic environment has been shown to influence the efficacy of anti-cancer drugs. This study aimed
Publikováno v:
Life Sciences. 215:246-252
Aim Opioid-induced bowel syndromes deteriorate patients' quality of life and may lead to nonadherence to opioid schedule and under-treatment of pain. The objective was to characterize the pharmacological profile of 17-cyclopropylmethyl-6,7-didehydro-
Publikováno v:
Life Sciences. 213:109-115
Aim Lipopolysaccharide (LPS)-induced myocardial injury is a leading cause of death in patients with sepsis, which is associated with excessive activation of PKCβ (especially PKCβ2) and autophagy. Remifentanil, a μ-opioid receptor agonist, is well
Autor:
Beatrice Ferrari, Paola Veneroni, Irene Masiello, Valentina Astesana, Beatrice Rangone, Ilaria Zanellato, Domenico Osella, Maria Grazia Bottone
Publikováno v:
Life Sciences. 210:166-176
Aims Neuroblastoma is a rare cancer that affects children, mostly under the age of 5. This type of cancer starts in very early forms of immature nerve cells or developing cells found in embryo or fetus. To date cisplatin represents one of the most po
Autor:
Yosra M. Magdy, Amina Ahmed Sedky
Publikováno v:
Life sciences. 278
Background Diabetes and psychotic disorders are occasionally comorbid. Possible pathophysiologies linking these disorders include inflammation and oxidative stress. Glucagon like peptide-1 (GLP-1) agonists modulate glucose metabolism and may exert ne