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Publikováno v:
Life Sciences. 230:97-103
Aim Acetaminophen (APAP) overdose is the most frequent cause of drug-induced liver damage. Magnolia officinalis is a traditional hepatoprotective Chinese medicine and Honokiol (HO) is the major active constituent. The present study was to investigate
Autor:
Sajad Jeddi, Pedro González-Muniesa, Mahboubeh Ghanbari, Hanieh Gholami, Asghar Ghasemi, Reza Norouzirad, Mehdi Hedayati
Publikováno v:
Life Sciences. 230:188-196
Aims Hyperoxia has beneficial metabolic effects in type 2 diabetes. However, hyperoxia exacerbates already existing oxidative stress in type 2 diabetes. Nitrate, a nitric oxide donor, is an effective new treatment in type 2 diabetes and also has anti
Publikováno v:
Life sciences. 280
Canagliflozin is an antidiabetic agent which lowers blood glucose levels by inhibiting the glucose reabsorption machinery in the proximal tubules. There have not been conducted any study on its direct impact on hypercholesterolemia and associated vas
Autor:
Ruixiao Wang, Alexander Tamalunas, Christian G. Stief, Beata Rutz, Bingsheng Li, Cora Sauckel, Ru Huang, Anna Ciotkowska, Martin Hennenberg, Christian Gratzke
Publikováno v:
Life sciences. 281
Aims Medical treatment for lower urinary tract symptoms secondary to benign prostatic hyperplasia is characterized by an unfavorable balance between limited efficacy and pronounced side effects. We recently reported, that thalidomide reduces prostate
Autor:
Mohamed A. Nassan, Amany Abdel-Rahman Mohamed, Shefaa A.M. El-Mandrawy, Safaa I. Khater, Ahmed Hamed Arisha, Lamiaa L.M. Ebraheim, Amany Tharwat Mohammed, Samar Abdo
Publikováno v:
Life sciences. 279
One of the global alarming prevalent metabolic diseases is Type 2 diabetes mellitus (T2DM) than other diabetes and sustains a substantial burden on public and healthcare systems. This study attempts to endeavor the beneficial effect of chitosan stabi
Autor:
Ertugrul Celik, Zehra Cicek, Ozbeyen Atalay, Gokhan Burcin Kubat, Oner Ulger, Serpil Suvay, Mehmet Ozler
Publikováno v:
Life sciences. 279
Aims Acetaminophen (APAP) toxicity is one of the leading causes of acute liver injury-related death and liver failure worldwide. In many studies, mitochondrial dysfunction has been identified as an important cause of damage in APAP toxicity. Therefor
Autor:
Luiz Gustavo de Almeida Chuffa, Carmen Rodríguez, Ramaswamy Sharma, Sergio Rosales-Corral, Vanesa Martín, Debora Aparecida Pires de Campos Zuccari, Russel J. Reiter
Publikováno v:
Life sciences. 278
This brief review describes the association of the endogenous pineal melatonin rhythm with the metabolic flux of solid tumors, particularly breast cancer. It also summarizes new information on the potential mechanisms by which endogenously-produced o
Publikováno v:
Life sciences. 279
Diabetes mellitus (DM) is a major metabolic disorder and an increasing health problem worldwide. Effective non-invasive therapies for DM are still lacking. Here, we have developed Microcurrent electrical nerve stimulation (MENS), a non-invasive thera
Publikováno v:
Life sciences. 278
Aims To determine if treatment with the selective serotonin reuptake inhibitor (SSRI) sertraline reduces the bladder dysfunction caused by water avoidance stress in mice. Main methods Adult female mice were randomly allocated to (1) Unstressed, (2) S
Autor:
Surya Kant Tripathi, Bijesh K. Biswal
Publikováno v:
Life sciences. 277
Aims The first-generation epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI), gefitinib, continues to be a primary treatment option for lung cancer patients. However, acquisition of resistance to gefitinib is a major obstacle in lu