Zobrazeno 101 - 110
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Publikováno v:
Life Sciences. 209:267-273
Objective Wnt/β‑catenin signaling pathway plays important role in colorectal cancer (CRC) and acts as a potential therapeutic target. Pimozide is a FDA-approved clinical drug used to treat psychotic diseases and it has shown anticancer effect in s
Publikováno v:
Life Sciences. 209:140-148
Aim Cynomorium songaricum Rupr., an edible and important Traditional Chinese medicine has long been used in folk for treatment of kidney deficiency, was chosen to estimate the antiosteoporotic activity and underlying molecular mechanism on rats induc
Publikováno v:
Life Sciences. 207:508-515
Aims In this study, we aimed to investigate the direct effects of steroid hormones on pregnant myometrial contraction. Main methods The effect of steroids on oxytocin-induced contraction was examined in vitro using pregnant rat or human myometrium. S
Autor:
Mohamed Balaha, Samah Kandeel
Publikováno v:
Life Sciences. 207:499-507
Aims The alkali-induced corneal injury is an ocular emergency that required an immediate and effective management to preserve the normal corneal functions and transparency. Olopatadine is a fast, topically-effective anti-allergic drug, which exhibite
Autor:
Esraa M. Mosalam, Eman G. Khedr, Nahla E. El-Ashmawy, Abdel-Aziz A. Zidan, El-Zeiny M. Ebeid, Mohamed L. Salem
Publikováno v:
Life Sciences. 207:461-470
Aims This study aimed to elucidate the benefits of nanoformulation of doxorubicin (DOX) and thymoquinone (TQ) loaded with nanofibers of poly-N-acetyl glucosamine (pGlcNAc), which is known as F2 gel, over their conventional free forms. Moreover, evalu
Autor:
Vahid Rahmanian, Kiavash Hushmandi, Ali Zarrabi, Mohammad Hossein Gholami, Kothanahally S. Sharath Kumar, Amirhossein Zabolian, Milad Ashrafizadeh, Yarabahally R. Girish, Pooyan Makvandi, Farid Hashemi, Amir Reza Aref, Sepideh Mirzaei, Haroon Khan, Maliheh Entezari
Publikováno v:
Life sciences. 277
Although chemotherapy is a first option in treatment of cancer patients, drug resistance has led to its failure, requiring strategies to overcome it. Cancer cells are capable of switching among molecular pathways to ensure their proliferation and met
Publikováno v:
Life sciences. 277
Aims The current study aims to investigate the role of the key effector cytokines produced by CD4+T cells in the pathogenesis of Con A-induced liver injury in mice and testing whether etanercept can be repurposed to differentially regulate these cyto
Autor:
Mehdi Yousefi, Hamed Mohammadi, Angelina Olegovna Zekiy, Ehsan Ansari Dezfouli, Farnaz Hajizadeh, Mohsen Nabi Afjadi, Vahid Karpisheh, Hadi Hassannia, Ata Mahmoodpoor, Farhad Jadidi-Niaragh, Mohammad Hojjat-Farsangi, Sanam Dolati, Navneet Joshi, Seyedeh Mahboubeh Mousavi
Publikováno v:
Life sciences. 275
Aims Despite extensive efforts to find new treatments, chemotherapy is still one of the first and foremost choices for cancer treatment. The main problems of using these drugs are the resistance of cancer cells and reducing their sensitivity to chemo
Autor:
Rehab A. Hasan, Rania A. Elrashidy
Publikováno v:
Life sciences. 278
Aims Hemorrhagic cystitis (HC) is a major urotoxic complication of cyclophosphamide (CPA) therapy. This study investigated the uroprotective effect of montelukast on CPA-induced HC, compared to the efficacy of 2-mercaptoethane sulfonate sodium (MESNA
Publikováno v:
Life sciences. 277
Cisplatin is one of the most potent anti-cancer drugs used for the treatment of various solid tumors, yet it has several side effects that may limit its clinical use. Hepatotoxicity is one of the most serious side effects as it may lead to liver fail