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pro vyhledávání: ''
Autor:
Ruixiao Wang, Alexander Tamalunas, Christian G. Stief, Beata Rutz, Bingsheng Li, Cora Sauckel, Ru Huang, Anna Ciotkowska, Martin Hennenberg, Christian Gratzke
Publikováno v:
Life sciences. 281
Aims Medical treatment for lower urinary tract symptoms secondary to benign prostatic hyperplasia is characterized by an unfavorable balance between limited efficacy and pronounced side effects. We recently reported, that thalidomide reduces prostate
Autor:
Ertugrul Celik, Zehra Cicek, Ozbeyen Atalay, Gokhan Burcin Kubat, Oner Ulger, Serpil Suvay, Mehmet Ozler
Publikováno v:
Life sciences. 279
Aims Acetaminophen (APAP) toxicity is one of the leading causes of acute liver injury-related death and liver failure worldwide. In many studies, mitochondrial dysfunction has been identified as an important cause of damage in APAP toxicity. Therefor
Autor:
Surya Kant Tripathi, Bijesh K. Biswal
Publikováno v:
Life sciences. 277
Aims The first-generation epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI), gefitinib, continues to be a primary treatment option for lung cancer patients. However, acquisition of resistance to gefitinib is a major obstacle in lu
Publikováno v:
Life sciences. 280
Aims Saxagliptin, a selective/potent dipeptidyl peptidase-4 inhibitor, has revealed remarkable anti-inflammatory features in murine models of nephrotoxicity, hepatic injury, and neuroinflammation. However, its potential effect on ethanol-induced gast
Autor:
Utpal Nandi, Ekta Nehra, Gurdarshan Singh, Amit Kumar, Payare L. Sangwan, Ashish Dogra, Divya Gupta, Shakti Kumar Dhiman, Sheikh Tasduq Abdullah, Swarnendu Bag, Irfan Ahmed, S. B. Bhatt
Publikováno v:
Life sciences. 278
Despite unprecedented advances in modern medicine, no safe and effective drug is available to date for oral administration to combat drug-induced liver injury, which is a vital concern nowadays. The present study deals with the hepatoprotective effec
Autor:
Kyung-Chul Choi, Cho-Won Kim
Publikováno v:
Life sciences. 277
Mitochondria are organelles that play a pivotal role in the production of energy in cells, and vital to the maintenance of cellular homeostasis due to the regulation of many biochemical processes. The heart contains a lot of mitochondria because thos
Autor:
Suseela Yelumalai, Ajlaa Sofya Mohd Khalil, Huma Shahzad, Naguib Salleh, Eswar Kumar Kilari, Nelli Giribabu
Publikováno v:
Life sciences. 278
Diabetes mellitus (DM) may lead to testicular-related infertility while Myristic acid (MA) is beneficial to lower hyperglycaemia. Thus, we hypothesized that MA could protect testes against hyperglycaemia-induced damage in DM. DM was induced in adult
Autor:
Masoumeh Haghbin Nazarpak, Amin Mahoutforoush, Soheil Abbaspour-Ravasjani, Atefeh Solouk, Hamed Hamishehkar
Publikováno v:
Life sciences. 279
Cancer-targeted co-delivery of therapeutic agents has been recognized as an effective strategy for increasing efficacy and reducing side effects of therapeutic agents. In this study, we used methotrexate (MTX) alone as a targeting moiety and chemothe
Autor:
Dalia H. El-Kashef, Marwa S. Serrya
Publikováno v:
Life Sciences. 228:266-273
Sitagliptin is an oral hypoglycemic drug that acts by selective inhibition of dipeptidyl peptidase-4 (DDP-4) enzyme. Aim This study scrutinized the hepatoprotective impact of sitagliptin) against thioacetamide (TAA)-induced liver damage in mice. Main
Publikováno v:
Life Sciences. 228:145-151
Aims Cisplatin (CP) is a widely used broad-spectrum antineoplastic agent used to treat a variety of human malignancies. Neurotoxicity is clinically evident in patients who have undergone a full course of chemotherapy. The aim of this study was to inv