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Autor:
Dalia H. El-Kashef, Marwa S. Serrya
Publikováno v:
Life Sciences. 228:266-273
Sitagliptin is an oral hypoglycemic drug that acts by selective inhibition of dipeptidyl peptidase-4 (DDP-4) enzyme. Aim This study scrutinized the hepatoprotective impact of sitagliptin) against thioacetamide (TAA)-induced liver damage in mice. Main
Publikováno v:
Life Sciences. 228:145-151
Aims Cisplatin (CP) is a widely used broad-spectrum antineoplastic agent used to treat a variety of human malignancies. Neurotoxicity is clinically evident in patients who have undergone a full course of chemotherapy. The aim of this study was to inv
Autor:
Yunpeng Xie, Yunlong Xia, Yun-Long Zhang, Hui-Hua Li, Xiaolei Yang, Jie Gu, Yang Liu, Xin Huang, Song Lai
Publikováno v:
Life Sciences. 227:94-100
Aims Improvements in cancer treatment have significantly extended the lifespan of patients. However, due to the adverse effects of cancer treatment, cancer survivors are at increased risk of cardiovascular complications. Doxorubicin is a widely used
Autor:
Osama Yousef Althunibat, Mohammad H. Abukhalil, Mousa O. Germoush, Amir M. Al Hroob, Ayman M. Mahmoud, May Bin-Jumah
Publikováno v:
Life Sciences. 221:83-92
Aims Hyperglycemia-mediated oxidative damage has been described as a major mechanism leading to pathologic changes associated with diabetic cardiomyopathy (DCM). Fisetin is a bioactive flavonol molecule found in many plants and possesses various biol
Autor:
Govindasamy Kanimozhi, M. Ganesan, Balupillai Agilan, Ramasamy Karthikeyan, Pierson Rathinaraj, Nirmal R. Madahavan, Nagarajan Rajendra Prasad
Publikováno v:
Life Sciences. 217:110-118
Aim The present study was designed to examine the role of alpha-pinene (AP) against skin photoaging in UVA-irradiated mice. Materials and methods Swiss albino mice were subjected to UVA-irradiation at the rate of 10 J/cm2 per day for ten days, totall
Publikováno v:
Life Sciences. 208:64-71
Nephrotoxicity is a serious adverse effect frequently encountered with aminoglycosides administration. Given the value of aminoglycosides in management of serious infections, nephro-protection is highly recommended. The current study investigated the
Autor:
Hong-Mei Hu, Xing-Chen Zhou, Wei Li, Chun-Nan Li, Qiong-Lan Yuan, Yu-Hui Hu, Mu-Hua Mao, Sheng Li, Cai-Fen Chen
Publikováno v:
Life sciences. 277
Dental pulp stem cells (DPSCs) possess the ability of multi-lineage differentiation, and are excellent sources of tissue engineering and regenerative medicine. Oxygen concentration and inflammation are two critical environmental factors that affect t
Publikováno v:
Life sciences. 266
Aims Cilostazol (Cilo), a phosphodiesterase-III inhibitor, has signified its efficacy against different ischemia/reperfusion (IS/RE) models. Nevertheless, it has not fully illuminated its potential effect against intestinal IS/RE-induced lung injury.
Publikováno v:
Life sciences. 266
Prenatal exposure to arsenic is demonstrated to elevate the risk of brain damage and neurological disorders in the fetus, mainly due to its ability for crossing through the placental barriers. Increase in oxidative stress, inflammation, and DNA damag
Publikováno v:
Life sciences. 271
Background Sevoflurane (Sevo) is neuroprotective in brain damage, thus our objective was to further investigate the impact of Sevo treatment on nerve regeneration and repair of neurological deficit in brain damage rats by regulating miR-490-5p and cy