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Publikováno v:
Life Sciences. 230:162-168
Aims Jumonji AT-rich interactive domain 2 (Jarid2) is an interacting component of PRC2 which catalyzes methylation of H3K27 (H3K27me3) and causes the downregulation of PTEN. In the present study, we aimed to explore whether Jarid2 could interact with
Autor:
Rajakishore Mishra, Manzar Alam
Publikováno v:
Life sciences. 280
Background Bcl-xL is an anti-apoptotic molecule, but its role in the progression and recurrent/ drug-resistant oral squamous cell carcinoma (OSCC) is poorly understood. Materials and methods A total of one hundred twenty-five human OSCC tissue specim
Autor:
Cailan Xiao, Yan Li, Na Liu, Jinhai Wang, Xiaoliang Gao, Lu Qiao, Jian Wu, Ning Xie, Chenyang Qiao, Yongquan Shi, Yuru Bai, Wei Hou
Publikováno v:
Life sciences. 277
Background Hepatocellular carcinoma (HCC) is one of the common malignancies worldwide. Slit-Robo GTPase-activating proteins (SRGAPs) have been shown to regulate the occurrence and development of various tumors. However, their specific roles in HCC re
Publikováno v:
Life sciences. 278
Objective Pancreatic cancer (PC) cells-derived exosomes could mediate angiogenesis of human microvascular endothelial cells (HUVECs) in PC. Considering that, this research was implemented to figure out the concrete role of PC cells-derived exosomal l
Autor:
Qiang Zhang, Jiancheng Song, Xia Xiangping, Fang Cao, Yao Shengtao, Yinchun Fan, Qian Liu, Yu Guo
Publikováno v:
Life sciences. 270
Aims Polo-like kinase 2 (PLK2) belongs to a family of serine/threonine kinases, and it is involved in tumorigenesis. The present study aimed to explore the potential clinical significance of PLK2 in the development of gliomas. Main methods Immunohist
Publikováno v:
Life sciences. 269
Identifying miRNAs involved in cancer and devising strategies to control their expression is a new therapeutic approach. Valproic acid (VPA) has attracted a lot of interest in cancer research. We evaluated the impact of VPA on the expression of miR-3
Autor:
Silvana Cugliari, Federico Jauk, Mariángeles Díaz, Marta Zerga, Nancy Cristaldo, Erica Rojas-Bilbao, Myriam Nuñez, Dorotea Fantl, Natalia Schutz, Victoria Otero, Angélica María Gamboa-Cedeño, Hernán García Rivello, Stella Maris Ranuncolo
Publikováno v:
Life sciences. 268
The challenge in classical Hodgkin Lymphoma (cHL) management is the 30-40% of refractory/relapsed cases.The aim of this work was to determine whether NIK and BCL-2 could be useful as prognosis biomarkers in cHL. In addition, we evaluated BCL-2 as a d
Publikováno v:
Life sciences. 268
Aims This study aimed to characterize the functions of pseudogene-derived long non-coding RNA (lncRNA) FAM207BP in lung adenocarcinoma (LUAD). Materials and methods Through the Cancer Genome Atlas (TCGA)-Genotype Tissue Expression (GTEx) database, FA
Autor:
Reza Safaralizadeh, Behzad Baradaran, Seyed Mahdi Banan Khojasteh, Mohammad Ali Hosseinpourfeizi, Narges Dastmalchi
Publikováno v:
Life sciences. 259
Aims MicroRNAs (miRs) are key modulators of cellular processes such as proliferation, apoptosis, as well as anti-cancer immune responses. Here, we evaluated the role of miR-424-5p in breast cancer (BC) and investigated its effects on T cell-related i
Publikováno v:
Life sciences. 262
Aims Lung cancer represents as the most prevalent tumor globally, among which non-small cell lung cancer (NSCLC) takes up for more than 80%. Lysine demethylase 4A (KDM4A) was dysregulated in NSCLC, but its role on the tumorigenesis in NSCLC cells and