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Publikováno v:
Life Sciences. 215:64-72
Non-alcoholic fatty liver disease (NAFLD) derives from the accumulation of hepatic lipids, which leads to liver steatosis and then triggers non-alcoholic steatohepatitis, sometimes worsening to hepatic fibrosis, cirrhosis, and hepatocellular carcinom
Publikováno v:
Life Sciences. 215:73-79
Aims Ovarian cancer is the most leading cause of deaths among gynecologic malignancies, and Neuron-restrictive silencer factor (NRSF) can be upregulated or downregulated according to the type of tumor. However, the expression and function of NRSF in
Publikováno v:
Life Sciences. 215:11-21
Aims Hepatic encephalopathy (HE) is a complex neuropsychiatric syndrome. Paracetamol (APAP) causes, in high doses, a hepatic injury. Alogliptin (ALO), with its 100% oral bioavailability, may be able to reverse the acute hepatic injury and memory impa
Publikováno v:
Life Sciences. 215:190-197
Aims Trefoil factor family member 2 (TFF2) is a small gut peptide. We have previously shown that Tff2 knock out (KO) mice are protected from high-fat (HF) diet-induced obesity (De Giorgio et al., 2013a). Thus, exploring Tff2 KO-related pathways of mi
Autor:
Sawsan Ibrahim Kreydiyyeh, Reem Rida
Publikováno v:
Life Sciences. 215:198-206
Aims Sphingosine-1-phosphate (S1P) has been implicated lately in inflammatory bowel disease which has diarrhea as one of its symptoms. Diarrhea is due to altered water movements as a result of altered electrolyte transport, and in particular sodium.
Publikováno v:
Life Sciences. 215:145-151
Alteration in microbial populations and metabolism are key events associated with disruption of intestinal homeostasis and immune tolerance during intestinal inflammation. A substantial imbalance in bacterial populations in the intestine and their re
Publikováno v:
Life Sciences. 214:118-123
P-glycoprotein (P-gp) is a member of ATP-binding cassette (ABC) superfamily which extrudes chemotherapeutic agents out of the cell. Suppression of this efflux activity has been the subject of numerous attempts to develop P-gp inhibitors. The aim of t
HIV-1 Nef-POTEE; A novel interaction modulates macrophage dissemination via mTORC2 signaling pathway
Autor:
Raj Kamal Tripathi, Monika Sachdev, Umeshkumar Vekariya, Saurabh Kumar Agnihotri, Poonam Singh, Aamir Nazir, Reshu Saxena, Supinder Kaur, Rekha Sachan, Sushila Kumari, Smrati Bhadauria, Kavita Rawat, Balawant Kumar
Publikováno v:
Life Sciences. 214:158-166
Aims Human immunodeficiency virus −1 [HIV-1] Nef, localizes in different cellular compartments and modulates several cellular pathways. Nef promotes virus pathogenicity through alteration in cell surface receptor expression, apoptosis, protein traf
Autor:
Zheng Shaozhong, Sun Chanjun, Fan Yingying, Pan Xue, Li Xiangnan, Zhang Kaishang, Li Zhenzhen, Zhang Yan
Publikováno v:
Life Sciences. 215:159-169
Twinfilin-1 (TWF1) has been implicated in cell motility, invasion and migration. However, its exact role in lung cancer progression is still unclear. In the present study, we explored clinical and prognostic relevance of Twinfilin-1 (TWF1) levels for
Publikováno v:
Life Sciences. 214:70-76
Aims CREB (cAMP response element-binding protein)-regulated transcription coactivator (CRTC2) has been reported to act as a coactivator of CREB during gluconeogenesis. The role of CRTC2 in osteoblastic differentiation has not yet been elucidated. The