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Autor:
Sawsan Ibrahim Kreydiyyeh, Reem Rida
Publikováno v:
Life Sciences. 215:198-206
Aims Sphingosine-1-phosphate (S1P) has been implicated lately in inflammatory bowel disease which has diarrhea as one of its symptoms. Diarrhea is due to altered water movements as a result of altered electrolyte transport, and in particular sodium.
Publikováno v:
Life Sciences. 212:159-167
Aims We investigate the consequence of adjuvant anastrozole (ANA) in monotherapy or associated with biochanin A (BCA) in ovariectomized (OVX) rat model and the degree of developing bone loss in both conditions. Materials and methods Sixty female rats
Publikováno v:
Life Sciences. 212:261-266
Aim The current study evaluates the anticonvulsant effect of valproic acid (VPA) alone or combined with low dose γ-irradiation (LDR) against pentylenetetrazol-induced convulsions in rats. Material and methods Five groups of rats were used, group I s
Efflux inhibition by H2S confers sensitivity to doxorubicin-induced cell death in liver cancer cells
Autor:
Tian Shuang, Guangdong Yang, Amadeo M. Parissenti, Eric Stokes, Lingyun Wu, Ming Fu, Baoqing Guo, Yanjie Zhang, Rui Wang, Yanxi Pei
Publikováno v:
Life Sciences. 213:116-125
Aims Hydrogen sulfide (H2S), an important gasotransmitter, is involved in a variety of cellular functions and pathophysiologic processes. Drug resistance due to alterations in drug trafficking and metabolism severely limits the effectiveness of cance
Autor:
Beatrice Ferrari, Paola Veneroni, Irene Masiello, Valentina Astesana, Beatrice Rangone, Ilaria Zanellato, Domenico Osella, Maria Grazia Bottone
Publikováno v:
Life Sciences. 210:166-176
Aims Neuroblastoma is a rare cancer that affects children, mostly under the age of 5. This type of cancer starts in very early forms of immature nerve cells or developing cells found in embryo or fetus. To date cisplatin represents one of the most po
Autor:
Fadia Mayyas, Karem H. Alzoubi
Publikováno v:
Life Sciences. 211:279-285
Aims Tobacco smoking is considered a global health issue, contributing to increased risk of cardiovascular disease (CVD) and diabetes (DM). We aimed to assess effects of cigarette smoking on cardiac inflammation, oxidative stress and fibrosis in rat
Autor:
Jie Xiong, Weili Wang, Dan Ma, Zhaoyuan Zhang, Kunlin Yu, Jishi Wang, Tianzhuo Zhang, Tingting Lu, Danna Wei, Qin Fang
Publikováno v:
Life Sciences. 211:224-237
Aims The aim of this study was to investigate the combinatorial effects of IM and a novel HDAC inhibitor AR-42 on the proliferation, apoptosis, cell cycle arrest, migration and invasion of CML cells, and to explore the underlying mechanisms. Main met
Publikováno v:
Life Sciences. 211:74-80
Aim Growth arrest and DNA-damage-inducible 45 beta (GADD45β) is a member of the gene family associated with cell growth control, apoptosis, and DNA damage repair. The aim of present study was to determine the potential effects of GADD45β deletion o
Publikováno v:
Life Sciences. 211:31-39
Aims This study investigated the effect of sitagliptin prophylactic treatment on intestinal I/R rat model and explored the possible underlying mechanism. Main methods Forty-five male Sprague-Dawley rats were randomly assigned to 3 groups: Sham group
Publikováno v:
Life Sciences. 209:111-121
Aims Astragaloside IV (As-IV) is the major active ingredient of Astragalus membranaceus and has diverse pharmacological activities, including anti-inflammatory and antioxidant effects. However, the beneficial effect of As-IV on protecting vascular en