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Autor:
Fadia Mayyas, Karem H. Alzoubi
Publikováno v:
Life Sciences. 211:279-285
Aims Tobacco smoking is considered a global health issue, contributing to increased risk of cardiovascular disease (CVD) and diabetes (DM). We aimed to assess effects of cigarette smoking on cardiac inflammation, oxidative stress and fibrosis in rat
Publikováno v:
Life Sciences. 209:111-121
Aims Astragaloside IV (As-IV) is the major active ingredient of Astragalus membranaceus and has diverse pharmacological activities, including anti-inflammatory and antioxidant effects. However, the beneficial effect of As-IV on protecting vascular en
Autor:
Dragica Gajić, Ivan Koprivica, Ivana Stojanovic, Andreas G. Tzakos, Tamara Saksida, Dimitris Diamantis, Nada Pejnovic, Natalija Jonić
Publikováno v:
Life Sciences. 288:120184
Aims Rosmarinic acid (RA) is a polyphenol that occurs in plants of the Lamiaceae family. Phenethyl ester of RA (PERA), a novel RA derivative, has been developed and evaluated in vivo in an animal model of type 1 diabetes (T1D). Methods T1D was induce
Autor:
Naif Abdullah Al-Dhabi, Santiagu Stephen Irudayaraj, Gopalsamy Rajiv Gandhi, Savarimuthu Ignacimuthu, Antony Stalin, K. Balakrishna
Publikováno v:
Life Sciences. 153:100-117
Aims This paper investigates the hypoglycemic activity of two derivatives of embelin (1) viz. 6-bromoembelin (2) and vilangin (3), in high-fat diet - STZ induced diabetic rats. Main methods The effects of 6-bromoembelin (2) and vilangin (3) on insuli
Publikováno v:
Life sciences. 211
Aims Hepatic oxidative stress and weak antioxidant defence system resulting in hepatic lesion, has been reported in diabetic rats. The present study investigated the possible hepatoprotective effects of Malaysian propolis (MP) in diabetic rats, on th
Publikováno v:
Life sciences. 206
Aims Apoptosis of podocytes plays a crucial role in diabetic nephropathy (DN) development, and astragaloside (AS-IV) has a significant impact on podocyte apoptosis. This study aims to explore the effect of AS-IV on diabetic nephropathy progression. M
Autor:
Laila A. Eissa, Mamdouh M. El-Shishtawy, Nehal M. Elsherbiny, Heba S. Said, Yara A. Samra, Gregory I. Liou
Publikováno v:
Life sciences. 157
Aims Hyperglycemia leads to elevation of oxidative stress and proinflammatory cytokines which are the main causes of diabetic nephropathy (DN). NLRP3 inflammasome and thioredoxin-interacting protein (TXNIP) are recently assumed to participate in the
Publikováno v:
Life sciences. 151
Background Diabetes mellitus is one of the most public metabolic disorders. It is mainly classified into type 1 and type 2. Echinochrome is a pigment from sea urchins that has antioxidant, anti-microbial, anti-inflammatory and chelating abilities. Ai