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Autor:
Sawsan Ibrahim Kreydiyyeh, Reem Rida
Publikováno v:
Life Sciences. 215:198-206
Aims Sphingosine-1-phosphate (S1P) has been implicated lately in inflammatory bowel disease which has diarrhea as one of its symptoms. Diarrhea is due to altered water movements as a result of altered electrolyte transport, and in particular sodium.
Publikováno v:
Life Sciences. 209:111-121
Aims Astragaloside IV (As-IV) is the major active ingredient of Astragalus membranaceus and has diverse pharmacological activities, including anti-inflammatory and antioxidant effects. However, the beneficial effect of As-IV on protecting vascular en
Publikováno v:
Life Sciences. 209:267-273
Objective Wnt/β‑catenin signaling pathway plays important role in colorectal cancer (CRC) and acts as a potential therapeutic target. Pimozide is a FDA-approved clinical drug used to treat psychotic diseases and it has shown anticancer effect in s
Autor:
Chang-Ju Kim, Min Seop Kwak, Jung Won Jeon, Il-Gyu Ko, Lakkyong Hwang, Hyun Phil Shin, In Taik Hong, Jin Hee Han, Jin Young Yoon, Eun-Sang Ji, Sung Eun Kim, Jun-Jang Jin
Publikováno v:
Life Sciences. 203:12-19
Aims The main action of proton pump inhibitors (PPIs) is to inhibit gastric acid secretion, and PPIs are widely used to treat gastric ulcer (GU). However, if the action of promoting gastric mucosal regeneration is added, the effectiveness of GU treat
Autor:
Mohammad Hossein Asghari, Emad Ghobadi, Mohammad Abdollahi, Marjan Fallah, Milad Moloudizargari
Publikováno v:
Life Sciences. 196:143-155
Our knowledge regarding the implications of melatonin in the therapy of numerous medical conditions, including cancer is constantly expanding. Melatonin can variably affect cancer pathology via targeting several key aspects of any neoplastic conditio
Autor:
Marisa Jádna Silva Frederico, Allisson Jhonatan Gomes Castro, Francieli Kanumfre de Carvalho, Leandro Espíndola, Gabrielle da Luz, Zenilda L. Bouzon, Éder C. Schmidt, Ana Luiza Ludwig Moraes, Moacir Geraldo Pizzolatti, Fátima Regina Mena Barreto Silva
Publikováno v:
Life Sciences. 154:58-65
Aim Triterpenes and their derivatives influence on carbohydrate metabolism. In vivo and in vitro treatment investigated the effect of the natural triterpene fern-9(11)-ene-2α,3β-diol ( 1 ), isolated from Croton heterodoxus , and a derivative triter
Autor:
Amin Isanejad, Najmeh Khojastehnjad, Saeed Khodayari, Vahid Khori, Sadegh Amani Shalamzari, Ali Mohammad Alizadeh, Hamid Khodayari
Publikováno v:
Life Sciences. 151:30-40
Aims MicroRNAs (miRNAs) are the targeting signal-transduction pathways that can mediate tumorigenesis via their down and/or up-regulation. For example, miR-21 and miR-206 can effect on the tumor angiogenesis as an oncomir and a tumor suppressor, resp
Publikováno v:
Life sciences. 213
Purpose Statins extended their hypocholestremic effect to show a promising anticancer activity. Hepatocellular carcinoma (HCC), the third common cause of cancer-related death, responded positively to statins. Some in-vitro studies reveal the rosuvast
Publikováno v:
Life sciences. 208
Aims Lupus nephritis (LN) is a kidney inflammatory disease caused by systemic lupus erythematosus (SLE). Both NF-κB activation and NLRP3 inflammasome activation are implicated in LN pathogenesis, suggesting they are potential targets for LN treatmen
Autor:
Waldiceu A. Verri, Tânia Longo Mazzuco, Roberto I. Tatakihara, Allan J. C. Bussmann, Mariana M. Bertozzi, Rubia Casagrande, Victor Fattori, Kenji W. Ruiz-Miyazawa, Sergio M. Borghi, Yuri Lourenco-Gonzalez
Publikováno v:
Life sciences. 208
Aims Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used and effective anti-inflammatories despite the well-known side effects such as gastrointestinal damage, acute kidney injury (AKI), and cardiovascular dysfunctions. Diclofenac is among