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Publikováno v:
Life Sciences. 212:159-167
Aims We investigate the consequence of adjuvant anastrozole (ANA) in monotherapy or associated with biochanin A (BCA) in ovariectomized (OVX) rat model and the degree of developing bone loss in both conditions. Materials and methods Sixty female rats
Autor:
Fadia Mayyas, Karem H. Alzoubi
Publikováno v:
Life Sciences. 211:279-285
Aims Tobacco smoking is considered a global health issue, contributing to increased risk of cardiovascular disease (CVD) and diabetes (DM). We aimed to assess effects of cigarette smoking on cardiac inflammation, oxidative stress and fibrosis in rat
Publikováno v:
Life Sciences. 211:31-39
Aims This study investigated the effect of sitagliptin prophylactic treatment on intestinal I/R rat model and explored the possible underlying mechanism. Main methods Forty-five male Sprague-Dawley rats were randomly assigned to 3 groups: Sham group
Publikováno v:
Life Sciences. 209:140-148
Aim Cynomorium songaricum Rupr., an edible and important Traditional Chinese medicine has long been used in folk for treatment of kidney deficiency, was chosen to estimate the antiosteoporotic activity and underlying molecular mechanism on rats induc
Publikováno v:
Life Sciences. 203:129-140
Aims Statins are the most widely used to lower elevated low-density lipoprotein levels and preventing cardiovascular diseases in humans. However, about 20% of patients treated with this medication suffer from statin-related myalgia. To this end, this
Autor:
Mariana Cerqueira Losacco, Carolina Fernanda Theodora de Almeida, Francemilson Goulart-Silva, Maria Tereza Nunes, Andressa Harumi Torelli Hijo, Patrícia Gama, Paula Bargi-Souza
Publikováno v:
Life Sciences. 202:35-43
Aims High fat diet consumes and thyroid hormones (THs) disorders may affect nutrients metabolism, but their impact on the absorptive epithelium, the first place of nutrients access, remains unknown. Our aim was to evaluate the intestinal morphology a
Autor:
Naser Amini, Mahmoudreza Hadjighasem, Mohammad Taghi Joghataei, Fatemeh Ramezani Kapourchali, Parisa Hayat, Nasim Vousooghi, Sara Ramezani
Publikováno v:
Life Sciences. 173:11-19
Aims Glioblastoma cancer stem-like cells (GCSCs) promote themselves proliferation by secreting the vascular endothelial growth factor A (VEGF A ) in an autocrine manner, positively regulated by phosphodiesterase IV (PDE4). In the current study, we in
Autor:
Chang Wang, Liang Xiong, Xiuying Wen, Yue Zhang, Ming-Wang Xu, Ningxu Li, Jiahui Fu, Hiroshi Takemori
Publikováno v:
Life Sciences. 173:107-115
Aims To investigate the roles of salt inducible kinase (SIK1) in high glucose-induced triglyceride accumulation in human hepatoma HepG2 cells as well as in the molecular mechanism by which metformin, a drug to treat diabetes, suppresses high glucose-
Publikováno v:
Life Sciences. 154:15-23
Background The objective of the present study was to evaluate the effect of combination of telmisartan with 5-flourouracil (5-FU) in gastric cancer cachexia induced by administering N -methyl- N ′-methyl- N -nitrosoguanidine (MNNG). Method MNND was
Autor:
Marisa Jádna Silva Frederico, Allisson Jhonatan Gomes Castro, Francieli Kanumfre de Carvalho, Leandro Espíndola, Gabrielle da Luz, Zenilda L. Bouzon, Éder C. Schmidt, Ana Luiza Ludwig Moraes, Moacir Geraldo Pizzolatti, Fátima Regina Mena Barreto Silva
Publikováno v:
Life Sciences. 154:58-65
Aim Triterpenes and their derivatives influence on carbohydrate metabolism. In vivo and in vitro treatment investigated the effect of the natural triterpene fern-9(11)-ene-2α,3β-diol ( 1 ), isolated from Croton heterodoxus , and a derivative triter