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Publikováno v:
Life Sciences. 212:159-167
Aims We investigate the consequence of adjuvant anastrozole (ANA) in monotherapy or associated with biochanin A (BCA) in ovariectomized (OVX) rat model and the degree of developing bone loss in both conditions. Materials and methods Sixty female rats
Publikováno v:
Life Sciences. 209:140-148
Aim Cynomorium songaricum Rupr., an edible and important Traditional Chinese medicine has long been used in folk for treatment of kidney deficiency, was chosen to estimate the antiosteoporotic activity and underlying molecular mechanism on rats induc
Autor:
Esraa M. Mosalam, Eman G. Khedr, Nahla E. El-Ashmawy, Abdel-Aziz A. Zidan, El-Zeiny M. Ebeid, Mohamed L. Salem
Publikováno v:
Life Sciences. 207:461-470
Aims This study aimed to elucidate the benefits of nanoformulation of doxorubicin (DOX) and thymoquinone (TQ) loaded with nanofibers of poly-N-acetyl glucosamine (pGlcNAc), which is known as F2 gel, over their conventional free forms. Moreover, evalu
Autor:
Aditi Jain, Vibha Rani
Publikováno v:
Life Sciences. 205:97-106
Aim Doxorubicin (Dox) is one of the most cardiotoxic anti-cancerous drug that is widely used for broad-range of cancers. There is an urgent need for developing cardio-oncological therapeutic interventions. Natural products having both anti-cancerous
Autor:
Aneta Rogalska, Agnieszka Marczak
Publikováno v:
Life Sciences. 205:38-44
Ovarian cancer is the most lethal gynecologic malignancy worldwide with extremely poor patient prognosis. Elucidation of the detailed mechanisms of action of drugs targeting this cancer type is necessary to optimize treatment efficacy. Epothilones, a
Publikováno v:
Life Sciences. 202:78-88
Aims This study investigated the hepatoprotective effects of both zafirlukast and vincamine and their possible role in the treatment of tamoxifen-induced liver injury in rats. Materials and methods Female Wistar rats were divided into five groups (10
Autor:
Naser Amini, Mahmoudreza Hadjighasem, Mohammad Taghi Joghataei, Fatemeh Ramezani Kapourchali, Parisa Hayat, Nasim Vousooghi, Sara Ramezani
Publikováno v:
Life Sciences. 173:11-19
Aims Glioblastoma cancer stem-like cells (GCSCs) promote themselves proliferation by secreting the vascular endothelial growth factor A (VEGF A ) in an autocrine manner, positively regulated by phosphodiesterase IV (PDE4). In the current study, we in
Autor:
Amin Isanejad, Najmeh Khojastehnjad, Saeed Khodayari, Vahid Khori, Sadegh Amani Shalamzari, Ali Mohammad Alizadeh, Hamid Khodayari
Publikováno v:
Life Sciences. 151:30-40
Aims MicroRNAs (miRNAs) are the targeting signal-transduction pathways that can mediate tumorigenesis via their down and/or up-regulation. For example, miR-21 and miR-206 can effect on the tumor angiogenesis as an oncomir and a tumor suppressor, resp
Publikováno v:
Life Sciences. 149:104-113
Aim To investigate the effects and mechanisms of miR-451a in the tamoxifen (TAM) resistance of breast cancer cells. Materials and methods TAM sensitive cells (MCF-7) and resistant cells (LCC2) were employed in the study. The lentivirus vectors of Lv-
Publikováno v:
Life sciences. 208
Aims Lupus nephritis (LN) is a kidney inflammatory disease caused by systemic lupus erythematosus (SLE). Both NF-κB activation and NLRP3 inflammasome activation are implicated in LN pathogenesis, suggesting they are potential targets for LN treatmen