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Publikováno v:
Life Sciences. 209:111-121
Aims Astragaloside IV (As-IV) is the major active ingredient of Astragalus membranaceus and has diverse pharmacological activities, including anti-inflammatory and antioxidant effects. However, the beneficial effect of As-IV on protecting vascular en
Publikováno v:
Life Sciences. 202:78-88
Aims This study investigated the hepatoprotective effects of both zafirlukast and vincamine and their possible role in the treatment of tamoxifen-induced liver injury in rats. Materials and methods Female Wistar rats were divided into five groups (10
Autor:
Yasser S. El-Sayed, Asmaa F. Khafaga
Publikováno v:
Life Sciences. 196:9-17
Aims Methotrexate (MTX) is an efficient cytotoxic drug used against various carcinogenic, inflammatory and autoimmune diseases; however, the hepatotoxicity of MTX limits its use. Therefore, the present study aimed to evaluate the potential hepatoprot
Autor:
Waldiceu A. Verri, Tânia Longo Mazzuco, Roberto I. Tatakihara, Allan J. C. Bussmann, Mariana M. Bertozzi, Rubia Casagrande, Victor Fattori, Kenji W. Ruiz-Miyazawa, Sergio M. Borghi, Yuri Lourenco-Gonzalez
Publikováno v:
Life sciences. 208
Aims Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used and effective anti-inflammatories despite the well-known side effects such as gastrointestinal damage, acute kidney injury (AKI), and cardiovascular dysfunctions. Diclofenac is among
Publikováno v:
Life sciences. 201
Aims This study was designed to assess the beneficial role of biochanin A (BCA) in the protection of the cutaneous and renal tissues of ovariectomized rats, even in those treated with anastrozole (ANA). Materials and methods For this purpose, 60 adul
Autor:
Giulia Anzalone, Anna Bonanno, Giusy Daniela Albano, Mirella Profita, Monica Moscato, Sally E. Wenzel, Caterina Di Sano, Loredana Riccobono
Publikováno v:
Life sciences. 192
Background Cigarette smoke extract (CSE) affects the expression of non-neuronal components of cholinergic system in bronchial epithelial cells and, as PEBP1/Raf-mediated MAPK1/2 and ERK1/2 pathway, promotes inflammation and oxidative stress. Aims We
Publikováno v:
Life sciences. 191
Aims The epidermal growth factor receptor (EGFR) and nucleotide-binding and oligomerization-domain containing 2 (NOD2) are important in cancer and in microbial recognition, respectively. These molecules trigger intracellular signaling pathways induci
Autor:
Ki-Duck Kim, Ming-Wei Zhou, Chang Deok Kim, Wei-Tian Yin, Ri-Hua Jiang, Jeung-Hoon Lee, Jin-Hyup Lee
Publikováno v:
Life sciences. 155
Aims Keratinocytes are the predominant cells in the epidermis, exerting their primary role of physical barrier through sophisticated differentiation process. In addition, keratinocytes contribute to the activation of innate immunity, providing the su
Publikováno v:
Life sciences. 152
Aims Acetaminophen (APAP) overdose leads to severe hepatotoxicity. Isoquercitrin exhibited potential hepatoprotective effect in our previous study. The present investigation aimed to evaluate the effect of isoquercitrin against APAP induced liver inj