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Publikováno v:
Life Sciences. 212:159-167
Aims We investigate the consequence of adjuvant anastrozole (ANA) in monotherapy or associated with biochanin A (BCA) in ovariectomized (OVX) rat model and the degree of developing bone loss in both conditions. Materials and methods Sixty female rats
Autor:
Fadia Mayyas, Karem H. Alzoubi
Publikováno v:
Life Sciences. 211:279-285
Aims Tobacco smoking is considered a global health issue, contributing to increased risk of cardiovascular disease (CVD) and diabetes (DM). We aimed to assess effects of cigarette smoking on cardiac inflammation, oxidative stress and fibrosis in rat
Publikováno v:
Life Sciences. 208:64-71
Nephrotoxicity is a serious adverse effect frequently encountered with aminoglycosides administration. Given the value of aminoglycosides in management of serious infections, nephro-protection is highly recommended. The current study investigated the
Publikováno v:
Life Sciences. 208:10-19
Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed for the treatment of pain and inflammation. Although it is well known that NSAIDs can suppress bone growth, remodelling and repair, they are largely used post-operatively and post-
Autor:
Aditi Jain, Vibha Rani
Publikováno v:
Life Sciences. 205:97-106
Aim Doxorubicin (Dox) is one of the most cardiotoxic anti-cancerous drug that is widely used for broad-range of cancers. There is an urgent need for developing cardio-oncological therapeutic interventions. Natural products having both anti-cancerous
Autor:
Aneta Rogalska, Agnieszka Marczak
Publikováno v:
Life Sciences. 205:38-44
Ovarian cancer is the most lethal gynecologic malignancy worldwide with extremely poor patient prognosis. Elucidation of the detailed mechanisms of action of drugs targeting this cancer type is necessary to optimize treatment efficacy. Epothilones, a
Autor:
Chang-Ju Kim, Min Seop Kwak, Jung Won Jeon, Il-Gyu Ko, Lakkyong Hwang, Hyun Phil Shin, In Taik Hong, Jin Hee Han, Jin Young Yoon, Eun-Sang Ji, Sung Eun Kim, Jun-Jang Jin
Publikováno v:
Life Sciences. 203:12-19
Aims The main action of proton pump inhibitors (PPIs) is to inhibit gastric acid secretion, and PPIs are widely used to treat gastric ulcer (GU). However, if the action of promoting gastric mucosal regeneration is added, the effectiveness of GU treat
Publikováno v:
Life Sciences. 202:78-88
Aims This study investigated the hepatoprotective effects of both zafirlukast and vincamine and their possible role in the treatment of tamoxifen-induced liver injury in rats. Materials and methods Female Wistar rats were divided into five groups (10
Autor:
Yasser S. El-Sayed, Asmaa F. Khafaga
Publikováno v:
Life Sciences. 196:9-17
Aims Methotrexate (MTX) is an efficient cytotoxic drug used against various carcinogenic, inflammatory and autoimmune diseases; however, the hepatotoxicity of MTX limits its use. Therefore, the present study aimed to evaluate the potential hepatoprot
Autor:
Mohammad Hossein Asghari, Emad Ghobadi, Mohammad Abdollahi, Marjan Fallah, Milad Moloudizargari
Publikováno v:
Life Sciences. 196:143-155
Our knowledge regarding the implications of melatonin in the therapy of numerous medical conditions, including cancer is constantly expanding. Melatonin can variably affect cancer pathology via targeting several key aspects of any neoplastic conditio