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Publikováno v:
Leukemialymphoma. 58(12)
Multiple myeloma (MM) is a hematological cancer with underlying causes associated with increased oxidative stress. Through signaling of their receptor RAGE, advanced glycation endproducts (AGEs) are known to increase oxidative stress associated with
Autor:
Lee Ratner, Jeannette Y. Lee, Richard F. Ambinder, Malek Faham, Sylvia Silver, Shelly Lensing, David H. Henry, Nina D. Wagner-Johnston, Ariela Noy
Publikováno v:
Leukemialymphoma. 58(12)
Patients with HIV are at increased risk for developing B-cell lymphomas likely due in part to chronic antigen stimulation leading to clonal immunoglobulin (Ig) gene rearrangements. Clonal Ig DNA has been identified in the plasma in patients with lymp
Autor:
Sergey Gorlatov, Ana Garrido, Kanti R. Rai, Rajendra N. Damle, Carol Moreno, Rosa Bosch, Miquel Granell, Albert Esquirol, Silvana Saavedra, Jorge Sierra, Irene Garcia, Emili Montserrat, Eva Puy Vicente, Julio Delgado, Nicholas Chiorazzi, Laura Blanco, Marta Pratcorona, Josep F. Nomdedeu, Rodrigo Martino, Alba Mora, Sonia Jansa, Gerardo Ferrer
Publikováno v:
Leukemialymphoma. 58(11)
In normal B-cells, B-cell antigen receptor (BCR) signaling can be negatively regulated by the low-affinity receptor FcγRIIb (CD32b). To better understand the role of FcγRIIb in chronic lymphocytic leukemia (CLL), we correlated its expression on 155
Autor:
Fusun Ozdemirkiran, Asli Subasioglu, Kaan Savasoglu, Asu Fergun Yilmaz, Kadriye Bahriye Payzin
Publikováno v:
Leukemialymphoma. 58(8)
The aim of the study was to examine the relation between additional chromosomal aberrations (ACAs) with major molecular response (MMR) and BCR-ABL kinase domain (KD) mutations in the long-term follow-up of the chronic myeloid leukemia (CML) disease.
Autor:
Giuseppe Mameli, Magdalena Niegowska, Maria Francesca Ruda, Francesca Barraqueddu, Luigi Podda, Fausto Dore, Leonardo Antonio Sechi, Claudio Fozza, Laura Dessì, Giovanna Corda
Publikováno v:
Leukemialymphoma. 58(2)
Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant disorder associated with a progression to multiple myeloma (MM). MM is a plasma cell malignancy with a chronic lymphoprol...
Autor:
Nigel Patton, Ian Prosser, Shir-Jing Ho, Tony Mills, John F. Seymour, Emma Link, Andrew Nicol, Diana Zannino, Mark Hertzberg, Melita Kenealy, Linda Cowan, Robin Filshie
Publikováno v:
Leukemialymphoma. 58(2)
Single agent azacitidine or immunomodulatory drugs are effective in myelodysplastic syndrome (MDS), with differing target mechanisms and toxicities. Objectives of this ALLG MDS3 study in clinically advanced MDS, AMML and low blast AML were to establi
Autor:
Wen Zheng, Guiqiang Wang, Xiao Pei Wang, Yu Qin Song, Chen Zhang, Weiping Liu, Ling Yan Ping, Jun Zhu
Publikováno v:
Leukemialymphoma. 57(6)
The exact incidence and severity of hepatitis B virus (HBV) reactivation after the withdrawal of prophylactic antiviral therapy (delayed HBV reactivation) is unknown. We retrospectively analyzed 107 newly diagnosed diffuse large B cell lymphoma patie
Autor:
Dennis D. Weisenburger, Alex F. Herrera, Joo Y. Song, Girish Venkataraman, Amy S. Duffield, Yuri Fedoriw, Young S. Kim, Tanya Siddiqi, Mir Alikhan, Xueli Liu, Joyce Murata-Collins
Publikováno v:
Leukemialymphoma. 57(4)
Burkitt lymphoma patients with bulky disease often have bone marrow involvement. However, leukemic presentation of Burkitt lymphoma in the absence of a mass (pure Burkitt leukemia; PBL) is uncommon. Both PBL and Burkitt lymphoma/leukemia, presenting
Autor:
Takahisa Yamashita, Michihide Tokuhira, Keiko Abe, Morihiro Higashi, Satoshi Fujino, Eiichi Arai, Jun-ichi Tamaru, Masahiro Kizaki
Publikováno v:
Leukemialymphoma. 57(1)
The interaction between tumor cells and the tumor microenvironment is essential in the development and progression of diffuse large B-cell lymphoma (DLBCL). Loss of human leukocyte antigen DR (HLA-DR) in DLBCL is a robust adverse prognostic marker. W
Autor:
M A Piris, Aránzazu García-Raso, Pilar Llamas, Margarita Sánchez-Beato, José A. García-Marco, Raul Cordoba, Beatriz Herreros, Joaquin Martinez-Lopez, Elena Domenech, Juan-F Garcia, Antonia Rodriguez
Publikováno v:
Leukemialymphoma. 57(1)
Biopsy samples of lymph nodes from 38 patients with CLL were analyzed. We found differential expression in 1092 genes in two different subgroups: 418 overexpressed in one subgroup and 674 in another. Molecular pathways identified in one subgroup appe