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Autor:
Vu H. Nguyen, Richard A. Larson, Olatoyosi Odenike, Amittha Wickrema, Hongtao Liu, John Anastasi, Susana R. Marino, Koen van Besien, Justin Kline, Viviane Schouten, Nitin Jain, Peter A. Savage, Loren Joseph, Wendy Stock, Jodie Ulaszek, Andrew S. Artz, Lucy A. Godley, Rangesh Kunnavakkam
Publikováno v:
Leukemialymphoma. 54(6)
Umbilical cord blood (UCB) stem cells are frequently employed for allogeneic stem cell transplant, but delayed myeloid and lymphoid immune reconstitution leads to increased risk of infections. We recently reported the clinical results of 45 patients
Publikováno v:
Leukemialymphoma. 54(6)
MDR1 encodes an adenosine triphosphate (ATP)-dependent efflux transporter that protects the body from environmental xenobiotics to maintain optimal health. Five single nucleotide polymorphisms (SNPs) of MDR1, T-2410C, T-129C, C1236T, G2677T/A and C34
Autor:
Filip Rázga, Blanka Robešová, Marek Borsky, Ivana Jeziskova, Zdenek Racil, Martina Lengerová, Dana Dvorakova, Jiri Mayer
Publikováno v:
Leukemialymphoma. 54(5)
The nucleophosmin 1 (NPM1) gene is one of the most commonly mutated genes in acute myeloid leukemia (AML), occurring in approximately 60% of adult cytogenetically normal AML (CN-AML). To date, these mutations have only been detected in cells of the m
Autor:
María José Herranz, Sergi Serrano, Beatriz Bellosillo, Ana B. Galván, Anna Puiggros, Ana Ferrer, Lara Nonell, María Rodríguez-Rivera, Silvia Pairet, Eva Gimeno, Eulàlia Puigdecanet, Eugenia Abella, Lourdes Florensa, Blanca Espinet, Marta Salido, Carme Melero, Francesc Solé
Publikováno v:
Leukemialymphoma. 54(5)
Chronic lymphocytic leukemia (CLL) is characterized by a highly variable clinical course. Del(11q) and del(17p), routinely studied by conventional G-banding cytogenetics (CGC) and fluorescence in situ hybridization (FISH), have been related to progre
Publikováno v:
Leukemialymphoma. 54(4)
This study analyzed the frequency of regulatory T cells (Tregs) in chronic lymphocytic leukemia (CLL) by multiparameter flow cytometric immunophenotyping. Patients showed significantly increased frequencies of Tregs as compared to controls, a signifi
Publikováno v:
Leukemialymphoma. 54(3)
PHF6 belongs to the plant homeodomain (PHD)-like finger (PHF) family, which has been implicated in multiple cellular functions including transcriptional regulation and epigenetic modification [1]. ...
Autor:
Gail J. Roboz, Stephen G. Jenkins, David Helfgott, Eric J. Feldman, Stephen J. Wilson, Kathy A. Fauntleroy, Rosemary Soave, David P. Calfee, Tsiporah B. Shore, Michael J. Satlin, Liang Chen, Thomas J. Walsh, Barry N. Kreiswirth
Publikováno v:
Leukemialymphoma. 54(4)
Carbapenem-resistant Enterobacteriaceae (CRE) are increasingly prevalent pathogens. However, little is known about their emergence in patients with hematologic malignancies. We identified 18 patients with hematologic malignancies over 3.5 years who d
Autor:
Gert Matthijs, Lies Knippenberg, Gert De Hertogh, David A. Owen, Annemarie Degroote, Marijke Spaepen, Louis Libbrecht, Xavier Sagaert, Thomas Tousseyn, Kathleen Lambein, David F. Schaeffer, Sara Vander Borght
Publikováno v:
Leukemialymphoma. 54(4)
In Helicobacter pylori gastritis, constant antigenic stimulation triggers a sustained B-cell proliferation. Errors made during this continuous DNA replication are supposed to be corrected by the DNA mismatch repair mechanism. Failure of this mismatch
Autor:
Ross L. Levine, Bing Zhang, David P. Schenkein, Kimberly Straley, Bruno C. Medeiros, Aparna Vasanthakumar, Daniel A. Pollyea, James L. Zehnder, Lucy A. Godley, Valeria Fantin, Omar Abdel-Wahab, Holbrook E Kohrt
Publikováno v:
Leukemialymphoma. 54(2)
Mutations in the isocitrate dehydrogenase (IDH) 1 and 2 genes are recurrent, frequent and prognostic in patients with acute myeloid leukemia (AML). IDH1 and IDH2 encode nicotinamide adenine dinucle...
Publikováno v:
Leukemialymphoma. 53(12)
Primary effusion lymphoma (PEL) is a rare lymphoma associated with Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV8), and characterized by a malignant body cavity effusion without solid organ or nodal involvement.