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pro vyhledávání: '"Hisashi Yamada"'
Autor:
Hisashi Yamada, Kotaro Hishiki, Emi Tsuchitani, Masaharu Akiyama, Yumi Kanegae, Koji Ozaki, Ken Kaito, Miyuki Ohta
Publikováno v:
Leukemia research. 74
Novel epigenetic therapies targeting bromodomain and extra-terminal (BET) family proteins have shown therapeutic efficacy in diverse hematologic malignancies and solid cancers. However, the mechanism of resistance remains poorly understood. In the pr
Autor:
Miyuki Agawa, Shinobu Saito, Yasuhiko Kano, Hisashi Yamada, Junko Horiguchi-Yamada, Yasuhiro Arakawa
Publikováno v:
Leukemia Research. 30:723-734
Depsipeptide (FK228), a histone deacetylase inhibitor, is a promising new anticancer agent. The mechanism of resistance to this agent was studied using KU812 cells. Depsipeptide-resistant KU812 cells expressed P-glycoprotein (P-gp) and their resistan
Autor:
Satsuki Iwase, Yusuke Furukawa, Hisashi Yamada, Shinobu Saito, Takeshi Kawano, Yasuhiko Kano, Junko Horiguchi-Yamada
Publikováno v:
Leukemia Research. 28:623-629
Bcr-Abl tyrosine kinase inhibitor induces apoptosis and erythroid differentiation of K562 cells. During this erythroid differentiation, c-Myc and cyclin D1 transcripts are transiently downregulated. Accordingly, we studied the effect of cyclin D1 ove
Autor:
Takeshi Kawano, Yoko Mikami-Terao, Osamu Yamada, Miyuki Agawa-Ohta, Hiroyuki Ida, Hisashi Yamada, Masaharu Akiyama
Publikováno v:
Leukemia Research. 35:416-418
We evaluated the molecular mechanism of telomerase activation by erythropoietin (EPO) in human erythroleukemic JAS-REN-A cells. Telomerase activity increased 3–4 fold after 3–24 h of culture with EPO and was associated with increases in c-myc mRN
Autor:
Junko Horiguchi-Yamada, Satsuki Iwase, Masaharu Akiyama, Nobuakira Takeda, Yasuhiro Arakawa, Hisashi Yamada, Tetsuaki Sekikawa, Hideaki Suzuki, Miyuki Agawa
Publikováno v:
Leukemia research. 31(11)
Adhesion is one of the important biologic characteristics of leukemic cells. We previously reported a new megakaryocytic-erythroid cell line, JAS-R. In this study, JAS-R cells were segregated into two types by the differences of attachment to culture