Zobrazeno 1 - 10
of 21
pro vyhledávání: '"11"'
Autor:
Guillermo Garcia-Manero, Sa A. Wang, Roberto N. Miranda, Lynne V. Abruzzo, Liping Zhang, Yanpeng Zhang, L. Jeffrey Medeiros, Robert P. Hasserjian, Ming Zhao, Naomi Galili, Azar Raza, Ying Hu
Publikováno v:
Leukemia Research. 35:351-357
Deletions of chromosome 11q[del(11q)] as part of a non-complex karyotype are infrequent in myelodysplastic syndromes (MDS), leaving the clinicopathologic and genetic features largely undefined. From three large medical centers over a 10-year period,
Autor:
Arcangelo Liso, Salvatore Mirto, Alessandra Santoro, Luisa Anelli, Antonella Zagaria, Vincenzo Liso, Giorgina Specchia, Francesco Albano, Mariano Rocchi
Publikováno v:
Leukemia Research. 29:855-858
The t(8;21)(q22;q22) rearrangement is observed in about 15% of acute myelocitic leukemia (AML) cases, while variant t(8;21) translocations are detected in 6–10% of AML patients positive for the 5′RUNX1/3′CBFA2T1 fusion gene. We report a detaile
Autor:
Carmen Mediano, Rosa Ana de la Chica, Josep Maria Manresa, Blanca Espinet, Marta Salido, Francesc Solé
Publikováno v:
Leukemia Research. 35:1066-1069
We assess the possible genotoxic effect of maternal smoking on amniotic fluid cells, based on the presence of an increasing of structural abnormality of the 11q23 band bearing the MLL gene rearrangements. In this observational and prospective study c
Autor:
Keizo Horibe, Mariko Eguchi, Yasuhide Hayashi, Noriko Miyamura, Katsuyoshi Koh, Minenori Eguchi-Ishimae, Eiichi Ishii, Hisamichi Tauchi, Naoko Kinukawa, Masahiro Hirayama, Daisuke Tomizawa
Publikováno v:
Leukemia Research. 32:1523-1529
The treatment outcome for infant acute lymphoblastic leukemia (ALL) with positive MLL gene rearrangements remains poor. We analyzed whether additional chromosomal abnormalities (ACA) other than 11q23 translocation could affect the disease behavior an
Autor:
José Kerbauy, Maria de Lourdes Lopes Ferrari Chauffaille, Daniella Marcia Maranhão Bahia, Maria Regina Regis Silva, Maura Romeo
Publikováno v:
Leukemia Research. 26:993-996
Karyotyping is important for diagnosis and prognosis of myelodysplastic syndrome (MDS). Using fluorescence in situ hybridization (FISH) either mitotic or interphase cells can be analyzed and a higher number of cells can be screened. This study evalua
Autor:
Pál Jáksó, Judit Hermesz, Donát Alpár, László Kereskai, László Pajor, Szabolcs Kosztolányi, Mariann Dávid, Béla Kajtár, Zsófia Nagy
Publikováno v:
Leukemia Research. 35:1114-1116
Bone marrow specimens from 185 patients with plasma cell disorders (PCD) were investigated by fluorescence in situ hybridization (FISH) in order to determine the temporal sequence of cytogenetic aberrations. In 25 cases combined FISH analysis has als
Autor:
Ricardo Morilla, Ian Titley, Evdokia M. Mandala, Manal O. Elnenaei, Shayne Atkinson, K Owusu-Ankomah, Dalal M. Jadayel, Daniel Catovsky, Estella Matutes
Publikováno v:
Leukemia Research. 25:115-123
The translocation (11;14)(q13;q32) and its molecular counterpart the BCL-1 rearrangement are features observed in mantle cell lymphoma (MCL) and less commonly in other B-cell disorders. This rearrangement leads to cyclin D1 overexpression, which may
Autor:
Christian Berthou, Marc De Braekeleer, Véronique Marion, Angèle Herry, Frédéric Morel, Marie Josée Le Bris, Nathalie Douet-Guilbert, Geneviève Le Calvez
Publikováno v:
Leukemia Research. 27:965-967
We report two adults with T-cell acute lymphoblastic leukemia (ALL). Cytogenetic studies at diagnosis with R banding showed a 46,XX,t(4;11)(q21;p15)/46,XX karyotype in one patient and 46,XY,t(1;4;11)(p32;q21;p15)/46,XY in the other. Fluorescence in s
Autor:
Sarah F. Paternoster, John M. Bennett, Athena M. Cherry, Kenneth B. Miller, Stephanie R. Brockman, Peter L. Greenberg, Gordon W. Dewald, Donna Neuberg, Rodney R. Higgins, Jacob M. Rowe, Martin S. Tallman, Gary A. Hicks
Publikováno v:
Leukemia Research. 27:1085-1090
Cytogenetic analysis can be important in determining the prognosis and diagnosis of a number of hematological disorders, including myelodysplastic syndromes (MDS). Here, we compared metaphase chromosomal analyses on bone marrow aspirates from MDS pat
Autor:
Carmen Silvia Passos Lima, Lilia Suárez Batista, Konradin Metze, Irene Lorand-Metze, E. Ribeiro
Publikováno v:
Leukemia research. 31(2)
The diagnosis of myelodysplastic syndromes (MDS) is based on peripheral cytopenias, bone marrow (BM) morphology and karyotyping. This may be difficult in cases with few dysplastic elements in BM and a normal karyotype. We examined the utility of flow