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Autor:
Isaura M. Frost, Roger A. Rajewski, John H. Bushweller, Trista E. North, Charles Schmidt, Anuradha Illendula, Zaw Min Oo, Wanda Kwan, Yunpeng Zhou, Jolanta Grembecka, Virginie Esain, Nancy A. Speck
Publikováno v:
Leukemia & Lymphoma. 59:2188-2200
The core binding factor (CBF) gene RUNX1 is a target of chromosomal translocations in leukemia, including t(8;21) in acute myeloid leukemia (AML). Normal CBF function is essential for activity of AML1-ETO, product of the t(8;21), and for survival of