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Autor:
Alexey V. Danilov, Jennifer R. Brown, J. Claire Godbersen, Cody Paiva, Olga V. Danilova, Allison Berger
Publikováno v:
Leukemia & Lymphoma. 56:1566-1569
Chronic lymphocytic leukemia (CLL) B-cells demonstrate both constitutive and stroma-mediated activation of nuclear factor-κB (NF-κB). NEDD8, a ubiquitin-like protein, regulates activity of Cullin-RING ubiquitin ligases (CRLs) and thus indirectly co