Zobrazeno 1 - 10
of 40
pro vyhledávání: '"11"'
Autor:
Wei Liu, Wen-Mei Yu, Mignon L. Loh, Jing Zhang, Cheng-Kui Qu, Rebecca J. Chan, Kevin D. Bunting, Zheng Zhang
Publikováno v:
Leukemia
Leukemia, vol 31, iss 6
Leukemia, vol 31, iss 6
Activating mutations, such as E76K and D61Y, in PTPN11 (SHP2), a protein tyrosine phosphatase implicated in multiple cell signaling processes, are associated with 35% of patients with juvenile myelomonocytic leukemia (JMML), an aggressive childhood m
Autor:
Lili Chen, Andrew G. Muntean, Wei Chen, Maria Mysliwski, Ari Melnick, Ross L. Levine, James Ropa, Justin Serio, Zaneta Nikolovska-Coleska, Rebecca J. Chan, Jay P. Patel, Fardokht A. Abulwerdi, Martin S. Tallman, Omar Abdel-Wahab, Elisabeth Paietta
Publikováno v:
Leukemia
PTPN11 encodes the Shp2 non-receptor protein-tyrosine phosphatase implicated in several signaling pathways. Activating mutations in Shp2 are commonly associated with juvenile myelomonocytic leukemia but are not as well defined in other neoplasms. Her
Autor:
Takayuki Honda, Kenichi Koike, C Iwashita, Shoji Saito, Kazuo Sakashita, Yozo Nakazawa, Koichi Hirabayashi, Kentaro Yoshikawa, Takashi Kurata, Kazuyuki Matsuda, Miyuki Tanaka, Ryu Yanagisawa, Sho Sasaki
Publikováno v:
Leukemia. 28:1545-1548
advance online publication, February 25, 2014
Juvenile myelomonocytic leukemia (JMML) is a fatal, mixed myeloproliferative and myelodysplastic disorder occurring in infancy and early childhood. Children with JMML have mutually exclusive genetic
Juvenile myelomonocytic leukemia (JMML) is a fatal, mixed myeloproliferative and myelodysplastic disorder occurring in infancy and early childhood. Children with JMML have mutually exclusive genetic
Autor:
Charles Craddock, Didier Blaise, Catherine Cordonnier, Ulrike Bacher, Johan Maertens, Liisa Volin, Arnon Nagler, Gérard Socié, Jordi Esteve, Noel-Jean Milpied, Florent Malard, M. Labopin, M. Mohty, Arnaud Pigneux
Publikováno v:
Leukemia. 29(12)
Acute myeloid leukemia (AML) with 11q23/MLL rearrangement (MLL-r AML) is allocated to the intermediate- or high-risk cytogenetic prognostic category depending on the MLL fusion partner. A more favorable outcome has been reported in patients receiving
Autor:
Isabelle Radford-Weiss, Julie Lachenaud, Pierre Brousset, Florence Nguyen-Khac, Stéphanie Struski, Christine J. Harrison, Hélène Cavé, Olivier Bernard, Véronique Della Valle, Elise Chapiro, Lisa J. Russell
Publikováno v:
Leukemia. 24:1362-1364
A new recurrent translocation t(11;14)(q24;q32) involving IGH@ and miR-125b-1 in B-cell progenitor acute lymphoblastic leukemia
Autor:
Philippe Bouillet, Stefan P Glaser, Seong Lin Khaw, Delphine Merino, David C.S. Huang, Andrew W. Roberts, Mary Ann Anderson
Publikováno v:
Leukemia. 28(6)
Overexpression of the prosurvival protein Bcl-2 marks many B-lymphoid malignancies and contributes to resistance to many commonly used chemotherapeutic agents. The first effective BH3 mimetic inhibitors of Bcl-2, ABT-737 and navitoclax, also target B
Publikováno v:
Leukemia. 12:1561-1564
Acute leukemias of the t(4;11) (MLL-AF4 fusion gene) type frequently have high white blood counts and extramedullary disease in multiple organs. In the present study we evaluated the hypotheses that this extensive disease is the result of extramedull
Publikováno v:
Leukemia. 12:623-626
A patient previously diagnosed with chronic neutrophilic leukemia (CNL) was studied using fluorescent in situ hybridization (FISH) to determine clonality of neutrophils. By cytogenetic studies the patient's blood and bone marrow had an 11q14 deletion
Autor:
Tanaka I, Takahiro Takahashi, Kazunori Nakase, Hiroshi Miwa, Masato Shikami, Kenkichi Kita, Nanao Kamada, Minoru Mizutani, Takanori Ueda, Motoko Yamaguchi, Kaori Nasu, H Dohy, Nadim Mahmud, Hiroshi Shiku
Publikováno v:
Scopus-Elsevier
In 227 of 495 (45.9%) Japanese adult patients with acute myelocytic leukemia (AML), leukemic cells expressed CD4. Incidence of CD4 expression in each FAB subtype was as follows: M1 37.4%, M2 33.7%, M3 35.4%, M4 65.0%, and M5 78.3%. The typical expres
Publikováno v:
Leukemia. 11:1827-1832
Agnogenic myeloid metaplasia (AMM) is a disease characterized by bone marrow megakaryocyte hyperplasia and clusters of megakaryocytes, in which many of the megakaryocytes are atypical. In order to elucidate the mechanisms of megakaryocytosis, ELISA a