Zobrazeno 1 - 10
of 14
pro vyhledávání: '"11"'
Autor:
Clara D. Bloomfield, Bayard L. Powell, Andrew J. Carroll, Shelley Orwick, Ann-Kathrin Eisfeld, Jessica Kohlschmidt, Bhavana Bhatnagar, Dimitrios Papaioannou, Richard Stone, Deedra Nicolet, Krzysztof Mrózek, John C. Byrd, Jonathan E. Kolitz, Christopher J. Walker, James S. Blachly
Publikováno v:
Leukemia. 34:358-368
Sole trisomies of chromosomes 4, 8, 11, 13 and 21 account for 89–95% of all sole trisomies in adult AML patients. We analyzed clinical and molecular characteristics of 138 de novo AML patients with sole +4, +8, +11, +13 or +21, and compared them wi
Autor:
Wei Liu, Wen-Mei Yu, Mignon L. Loh, Jing Zhang, Cheng-Kui Qu, Rebecca J. Chan, Kevin D. Bunting, Zheng Zhang
Publikováno v:
Leukemia
Leukemia, vol 31, iss 6
Leukemia, vol 31, iss 6
Activating mutations, such as E76K and D61Y, in PTPN11 (SHP2), a protein tyrosine phosphatase implicated in multiple cell signaling processes, are associated with 35% of patients with juvenile myelomonocytic leukemia (JMML), an aggressive childhood m
Autor:
Nelson Hamerschlak, Paulo Vidal Campregher, Jessica Schulman, Srdan Verstovsek, Hagop M. Kantarjian, Lucia Masarova, Maria E. Arcila, Ross L. Levine, Tarcila Santos Datoguia, Bartlomiej Getta, Raajit K. Rampal, Christopher Famulare, Renato David Puga, Raquel de Melo Alves Paiva, Fabio P.S. Santos
Publikováno v:
Leukemia
RAS-pathway mutations are recurrent events in myeloid malignancies. However, there is limited data on the significance of RAS-pathway mutations in patients with myelofibrosis (MF). We analyzed next-generation sequencing data of 16 genes, including RA
Autor:
Koshi Akahane, Marc R. Mansour, Daniel J. DeAngelo, Takaomi Sanda, David M. Weinstock, Thomas Radimerski, A T Look
Publikováno v:
Leukemia
We previously found that TYK2 tyrosine kinase signaling through its downstream effector phospho-STAT1 (p-STAT1) acts to upregulate BCL2, which in turn mediates aberrant survival of T-cell acute lymphoblastic leukemia (T-ALL) cells. Here we show that
Autor:
Lili Chen, Andrew G. Muntean, Wei Chen, Maria Mysliwski, Ari Melnick, Ross L. Levine, James Ropa, Justin Serio, Zaneta Nikolovska-Coleska, Rebecca J. Chan, Jay P. Patel, Fardokht A. Abulwerdi, Martin S. Tallman, Omar Abdel-Wahab, Elisabeth Paietta
Publikováno v:
Leukemia
PTPN11 encodes the Shp2 non-receptor protein-tyrosine phosphatase implicated in several signaling pathways. Activating mutations in Shp2 are commonly associated with juvenile myelomonocytic leukemia but are not as well defined in other neoplasms. Her
Autor:
Briana M. Richine, Ziyue Liu, Reuben Kapur, Elizabeth L. Virts, Baskar Ramdas, Bowling Jd, Raghuveer Singh Mali, Rebecca J. Chan, Boswell Hs, Zhong Yin Zhang, Naoye R
Publikováno v:
Leukemia
Syk kinase and Shp2 phosphatase inhibition cooperate to reduce FLT3-ITD-induced STAT5 activation and proliferation of acute myeloid leukemia
Autor:
Naval Daver, Hagop M. Kantarjian, Jorge E. Cortes, G. Garcia-Manero, E. Jabbour, Wei Qiao, Sherry Pierce, Tapan M. Kadia, Yiming Chen, M. de Lima, L. V. Abruzzo, Susan O'Brien, Farhad Ravandi, Partow Kebriaei, Stephan Faderl, Zeev Estrov
Publikováno v:
Leukemia. 27(4)
The clinical features and outcomes of 148 patients with acute myeloid leukemia (AML) and 11q23 chromosomal abnormalities were compared with those of 2640 patients with non-11q23 AML. Patients with t(9;11)), t(6;11), or other 11q23 balanced translocat
Autor:
Boswell Hs, Reuben Kapur, Menggang Yu, Xinna Zhang, Gen-Sheng Feng, Sarah C. Nabinger, Baskar Ramdas, Shifalika Goenka, Rebecca J. Chan, George E. Sandusky, Yantao He, Bowling Jd, Xing Jun Li, Briana M. Richine, Ziyue Liu, Zhong Yin Zhang, Li-Fan Zeng, Seiji Fukuda
Publikováno v:
Leukemia
Internal tandem duplications in the fms-like tyrosine kinase receptor (FLT3-ITDs) confer a poor prognosis in acute myeloid leukemia. We hypothesized that increased recruitment of the protein tyrosine phosphatase, Shp2, to FLT3-ITDs contributes to FLT
Autor:
Ana Izcue, Marie Bordas, Bola S. Hanna, Vicente Chapaprieta, Martina Seiffert, Laura Llaó-Cid, Stephan Stilgenbauer, Philipp M. Roessner, Sascha Dietrich, Selcen Öztürk, José I. Martín-Subero, Tobias Roider, Dolors Colomer
Publikováno v:
Leukemia
Leukemia : the Journal of Normal and Malignant Hemopoiese ; Official Journal of the Leukemia Research Fund U.K.
Leukemia : normal and malignant hemopoiesis 35(11), 3152-3162 (2021). doi:10.1038/s41375-021-01198-1
Leukemia : the Journal of Normal and Malignant Hemopoiese ; Official Journal of the Leukemia Research Fund U.K.
Leukemia : normal and malignant hemopoiesis 35(11), 3152-3162 (2021). doi:10.1038/s41375-021-01198-1
Leukemia : normal and malignant hemopoiesis 35(11), 3152-3162 (2021). doi:10.1038/s41375-021-01198-1
Published by Springer Nature, London
Published by Springer Nature, London
Autor:
Jennifer J. Wilkes, Henrique Bittencourt, Francesco Ceppi, Javier Oesterheld, Richard Sposto, Yoav Messinger, Susan R. Rheingold, Maria Luisa Sulis, David S. Ziegler, Rebecca Gardner, Weili Sun, Andrew E. Place, Robyn M. Dennis, Todd Cooper, Nobuko Hijiya, Anupam Verma, Yousif Matloub, Michelle L. Hermiston, Melissa Widener, Alan S. Wayne, Paul S. Gaynon, Kirk R. Schultz, Kenneth Heym, Van Huynh, Luciano Dalla-Pozza, Raymond J. Hutchinson, James A. Whitlock, Bill H. Chang, Jemily Malvar, Theodore W. Laetsch
Publikováno v:
Leukemia, vol. 32, no. 11, pp. 2316-2325
Leukemia, vol 32, iss 11
Leukemia
Leukemia, vol 32, iss 11
Leukemia
The survival of pediatric patients with multiply relapsed and/or refractory (R/R) B-cell acute lymphoblastic leukemia has historically been very poor; however, data are limited in the current era. We conducted a retrospective study to determine the o