Zobrazeno 1 - 10
of 104
pro vyhledávání: ''
Autor:
Henry Krum, Richard E. Gilbert
Publikováno v:
Lancet (London, England). 385(9982)
Summary Individuals with diabetes are not only at high risk of developing heart failure but are also at increased risk of dying from it. Fortunately, antiheart failure therapies such as angiotensin-converting-enzyme inhibitors, β blockers and minera
Autor:
Nihal Thomas, Lars Endahl, Andrew Lewin, Bernard Zinman, Julio Rosenstock, Rebecka Lindh, Chantal Mathieu, Greg Fulcher, Thue Johansen, Paturi V Rao, Michel Pinget
Publikováno v:
Lancet (London, England). 377(9769)
Summary Background Insulin degludec is a new basal insulin that forms soluble multihexamer assemblies after subcutaneous injection, resulting in an ultra-long action profile. This study aimed to assess efficacy and safety of insulin degludec injected
Autor:
Eric J. Brunner, Markus Jokela, Tasnime N. Akbaraly, Daniel R. Witte, Adam G. Tabak, Mika Kivimäki
Publikováno v:
Lancet (London, England). 373(9682)
Summary Background Little is known about the timing of changes in glucose metabolism before occurrence of type 2 diabetes. We aimed to characterise trajectories of fasting and postload glucose, insulin sensitivity, and insulin secretion in individual
Autor:
Nish, Chaturvedi, Massimo, Porta, Ronald, Klein, Trevor, Orchard, John, Fuller, Hans Henrik, Parving, Rudy, Bilous, Anne Katrin, Sjølie, Yit, Yang
Publikováno v:
Lancet (London, England). 372(9647)
Summary Background Results of previous studies suggest that renin-angiotensin system blockers might reduce the burden of diabetic retinopathy. We therefore designed the DIabetic REtinopathy Candesartan Trials (DIRECT) Programme to assess whether cand
Autor:
Varsha Parag, Stuart R Dalziel, Natalie Walker, Rea Hh, Jane E. Harding, Colin D. Mantell, Anthony Rodgers
Publikováno v:
Lancet (London, England). 365(9474)
Summary Background Antenatal betamethasone treatment is widely used for the prevention of neonatal respiratory distress syndrome in preterm infants and substantially reduces neonatal mortality and morbidity. Fetal exposure to excess glucocorticoids h
Autor:
P. M. Clark, Fiona M. Gribble, Roy Powell, Andrew T. Hattersley, Bryan J Starkey, Ewan R. Pearson
Publikováno v:
Lancet (London, England). 362(9392)
Summary Background Type 2 diabetes shows evidence of underlying heterogeneity. No studies have assessed whether different causes for diabetes change the response to oral hypoglycaemic therapy. In a few cases, patients with diabetes caused by mutation
Autor:
Hervé Leblanc, Jean-François Gautier, Patrick Vexiau, P. Antonio Tataranni, Eugène Sobngwi, Gilberto Velho, Fabien Calvo, Samy Hadjadj, Franck Mauvais-Jarvis, Raphaël Porcher, Richard E. Pratley, Philippe Boudou
Publikováno v:
Lancet (London, England). 361(9372)
Type 2 diabetes is affected by genetics and environmental factors. We aimed to assess the effect of an in-utero diabetic environment independently of the genetic background for type 2 diabetes.We measured insulin sensitivity and insulin secretion in
Autor:
Robert S. Lindsay, Jonathan Krakoff, Robert L. Hanson, Tohru Funahashi, P. Antonio Tataranni, Yuji Matsuzawa, Sachiyo Tanaka, William C. Knowler
Publikováno v:
Lancet (London, England). 360(9326)
Adiponectin is a collagen-like circulating protein secreted by adipocytes that is proposed to mediate obesity-related resistance to insulin. In a case-control series, we assessed the role of adiponectin in later development of type 2 diabetes in 70 p
Autor:
Anne Dornhorst
Publikováno v:
Lancet (London, England). 358(9294)
Summary The loss of early-phase insulin secretion is an important and early event in the natural history of type 2 diabetes. Because a normal pattern of insulin secretion is essential for the effective control of postprandial metabolism, a rational b
Publikováno v:
Lancet (London, England). 354(9188)
Chronic sleep debt is becoming increasingly common and affects millions of people in more-developed countries. Sleep debt is currently believed to have no adverse effect on health. We investigated the effect of sleep debt on metabolic and endocrine f