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Autor:
Debra Masel, Majed A. Refaai, Neil Blumberg, Omar S. Aljitawi, Michael Becker, Scott A. Kirkley, Kelly F. Henrichs, Amy E. Schmidt, Chelsea Milito
Publikováno v:
Laboratory Medicine. 50:396-400
The main clinical distinction between post-transfusion purpura (PTP) and idiopathic thrombocytopenic purpura (ITP) is the sudden development of severe thrombocytopenia in the days after transfusion. Herein, we report the case of a 53-year-old Caucasi
Autor:
Megan N Harley
Publikováno v:
Laboratory Medicine. 44:e92-e96
Sickle cell disease (SCD) occurs as a result of a genetic mutation that produces hemoglobin S (HbS), an abnormal type of hemoglobin (Hb). The HbS forms sickle-shaped red blood cells that adhere to vessel walls, causing bouts of pain commonly called v
Autor:
Chan Xie, Dong-Ying Xie, Zhi-liang Gao, Junqiang Xie, Liang Peng, Shao-Quan Zhang, Shi-Bin Xie
Publikováno v:
Laboratory Medicine. 41:551-556
Background: To investigate the biological characteristics and capacity of tumorigenicity of bone marrow mesenchymal stem cells (BMSCs) in the cancer environment. Methods: Bone marrow mesenchymal stem cells from 45 cancer patients and 20 non-cancer ad
Autor:
Farnaz Razmkhah, Ahmad Kazemi, Mojdeh Kalantarmotamedi, Vahid Pazhakh, Farhad Zaker, Shahin Negari, Parisa Rasighaemi, Mohsen Razavi, Mina Zarei
Publikováno v:
Laboratory Medicine. 41:547-550
Background: Imatinib mesylate is a drug used in treating chronic myeloid leukemia (CML). It induces apoptosis and inhibits cell proliferation. This study aimed to evaluate hematologic and molecular responses to Imatib (Cipla Limited, Mumbai, India) i
Autor:
Sara Taylor, Jonathan Yau
Publikováno v:
Laboratory Medicine. 41:517-521
Patient: A 58-year-old Caucasian female Chief Complaint: Altered mental status, fever. Also complains of occipital headache and neck pain. History of Present Illness: Patient had presented to the emergency department 11 days previously with intermitt
Autor:
David T. Harris
Publikováno v:
Laboratory Medicine. 39:173-178
Cord blood banking has been the focus of many medical centers as it can provide a virtually unlimited source of ethnically-diverse stem-cell donors. In addition, its recent use in several regenerative medicine clinical trials has further spurred the
Autor:
Gabriella Henel, John L. Schmitz
Publikováno v:
Laboratory Medicine. 38:428-436
Flow cytometry (FC) has become an important component in the diagnosis and monitoring of patients with a diverse array of diseases. While the basic principals underlying FC remain relatively unchanged, the technology and array of available reagents h
Autor:
Henry O. Ogedegbe
Publikováno v:
Laboratory Medicine. 38:295-304
Worldwide, chronic kidney disease has become a public health problem with increasing prevalence and high cost for treatment and prevention. It is projected that by 2030 there will be about 2 million patients needing dialysis and transplantation. Kidn
Autor:
Virginia C. Hughes
Publikováno v:
Laboratory Medicine. 31:672-678
Significant advances have been made in cord blood research and transplantation in the 20th century. More than 1,000 cord blood transplants have been performed worldwide, successfully treating disorders such as Fanconi anemia, chronic myelogenous leuk
Autor:
Nikolaos Grigoriadis, Ilyana Karvounidou, Vassilios Katsares, Zissis Paparidis, Karina-Alina Ardelean, Eleni Nikolaidou, Nestoras Drossas, John Grigoriadis
Publikováno v:
Laboratory Medicine. 40:437-439
Umbilical Cord Blood (UCB) is a major source of hematopoietic stem cells. Although there are numerous publications dealing with its efficacy for hematopoietic transplantations, very little is known concerning reference ranges for its hematological va