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pro vyhledávání: ''
Autor:
Gang Xu, Shuwang Ge, Kun Wang, Ying Yao, Ran Luo, Junhua Li, Meng Zhang, Lei Dong, Zhixiang Wang, Yichun Cheng
Publikováno v:
Kidney International
Kidney international, In Press
Kidney international, In Press
In December 2019, a coronavirus 2019 (COVID-19) disease outbreak occurred in Wuhan, Hubei Province, China, and rapidly spread to other areas worldwide. Although diffuse alveolar damage and acute respiratory failure were the main features, the involve
Autor:
Sen Zhao, Zhongchi Li, Gabriel Amador, Yanying Wang, Liyuan Li, Zhao Wang, Nannan Zhang, Kang Xu, Ying Qiu
Publikováno v:
Kidney International. 93:881-892
Sirtuin 6 (SIRT6) is a NAD+-dependent deacetylase associated with numerous aspects of health and physiology. Overexpression of SIRT6 has emerged as a protector in cardiac tissues against pathologic cardiac hypertrophy. However, the mechanism of this
Autor:
Hong Ruan, Wesley M. Raup-Konsavage, Weiwei Wang, Yanming Wang, W. Brian Reeves, Denis Feliers
Publikováno v:
Kidney International. 93:365-374
Ischemia/reperfusion is a common cause of acute kidney injury (AKI). However, mechanisms underlying the sudden loss in kidney function and tissue injury remain to be fully elucidated. Here, we investigated the role of peptidyl arginine deiminase-4 (P
Autor:
Zheng Dong, Guoping Fan, Shuang Huang, Han Fei Ding, Xiao Xiao, Jian Kang Chen, Chunyuan Guo, Lirong Pei, Qingqing Wei, Huidong Shi
Publikováno v:
Kidney International. 92:1194-1205
DNA methylation is an epigenetic mechanism that regulates gene transcription without changing primary nucleotide sequences. In mammals, DNA methylation involves the covalent addition of a methyl group to the 5-carbon position of cytosine by DNA methy
Autor:
Peter Igarashi, Christopher Y. Lu, Silvia Ferrè, Yingfeng Deng, Philipp E. Scherer, Sarah C. Huen, Orson W. Moe
Publikováno v:
Kidney Int
Sepsis is a systemic inflammatory state in response to infection, and concomitant acute kidney injury (AKI) increases mortality significantly. Endoplasmic reticulum stress is activated in many cell types upon microbial infection and modulates inflamm
Publikováno v:
Kidney International. 90:67-76
Tissue preconditioning, whereby various short term stressors initiate organ resistance to subsequent injury, is well recognized. However, clinical preconditioning of the kidney for protection against acute kidney injury (AKI) has not been established
Autor:
Ludger Johannes, Christian Marsching, Richard Jennemann, Damir Krunic, Christian Wunder, Roger Sandhoff, Ina Maria Schießl, Ivan Morace, Giuseppina Federico, Johanna von Gerichten, Viola Nordström, Hermann-Josef Gröne, Robert Pilz, Johannes Müthing
Publikováno v:
Kidney international. 96(2)
To elucidate the physiologic function of renal globotriaosylceramide (Gb3/CD77), which up-to-date has been associated exclusively with Shiga toxin binding, we have analyzed renal function in Gb3-deficient mice. Gb3 synthase KO (Gb3S−/−) mice disp
Publikováno v:
Kidney international. 95(4)
The 2012 Kidney Disease: Improving Global Outcomes (KDIGO) clinical practice guideline classifies acute kidney injury (AKI) into 3 stages defined by serum creatinine elevation or urine output decline. We evaluated the potential impact of further cate
Autor:
Xue Geng, Juan Liu, Xiaoying Xu, Fan Yi, Yi Lu, Yi Fu, Chun Zhang, Qiang Wan, Feng Liu, Meng Zhou, Ziying Wang, Wei Tang, Xinying Yang, Yan Zhang, Xinbing Wei, Ningjun Li
Publikováno v:
Kidney International. 87:918-929
Progranulin (PGRN), an autocrine growth factor, has multiple physiological functions and is widely involved in the pathogenesis of many types of diseases. The pivotal anti-inflammatory function of PGRN in rheumatoid arthritis encouraged us to examine
Autor:
Mary E. Fidler, Sanjeev Sethi, Nelson Leung, Anthony M. Valeri, Angela K. Muriithi, Samih H. Nasr, Lynn D. Cornell
Publikováno v:
Kidney International. 87:458-464
Acute interstitial nephritis (AIN) is an important cause of acute kidney injury (AKI), and its prevalence in the elderly may be increasing. It is largely unknown whether AIN in the elderly is similar to that in younger adults; therefore, we investiga