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of 167
pro vyhledávání: ''
Autor:
Rudolf P. Wüthrich, Daniel Rodriguez, Yang Liu, Olivier Devuyst, Suhua Zhang, Xueqi Wang, Nilufar Mohebbi, Stephan Segerer, Daniela Spichtig, Sarika Kapoor, Changlin Mei, Hermann Koepsell, Andreas L. Serra
Publikováno v:
Kidney international
Renal tubular epithelial cell proliferation and transepithelial cyst fluid secretion are key features in the progression of polycystic kidney disease (PKD). As the role of the apical renal sodium-glucose cotransporters in these processes is not known
Publikováno v:
Kidney International. 84:703-712
This study assessed whether endothelin-1 (ET-1) helps mediate postischemic acute kidney injury (AKI) progression to chronic kidney disease (CKD). The impact(s) of potent ETA or ETB receptor-specific antagonists (Atrasentan and BQ-788, respectively) o
Autor:
Shashi Shrivastav, Robin A. Felder, Pedro A. Jose, Hewang Lee, Icksoo Lee, Ines Armando, Maik Hüttemann, Annabelle P. Crusan, Jeffrey B. Kopp, Ulrich Hopfer, Yoshifusa Abe, Laureano D. Asico
Publikováno v:
Kidney international
Renal proximal tubule cells from spontaneously hypertensive rats (SHR), compared with normotensive Wistar–Kyoto rats (WKY), have increased oxidative stress. The contribution of mitochondrial oxidative phosphorylation to the subsequent hypertensive
Autor:
Nan He, Shiqin Zhang, Ryan Gillihan, Troy M. Green, Timothy A. Fields, Jason R. Stubbs, Shiguang Liu
Publikováno v:
Kidney international
Fibroblast growth factor 23 (FGF23) is a phosphaturic hormone that in end-stage renal disease is markedly increased in serum; however, the mechanisms responsible for this increase are unclear. Here, we tested whether phosphate retention in chronic ki
Autor:
Hui-Fang Cheng, Tomoki Miyazawa, Haichun Yang, Aihua Bian, Suwan Wang, Fenghua Zeng, Agnes B. Fogo, Raymond C. Harris, Xiaofeng Fan
Publikováno v:
Kidney international
Decreased nitric oxide bioavailability has an important role in the initiation and progression of diabetic nephropathy, but the underlying mechanisms remain unclear. Here, we found that heparin-binding epidermal growth factor-like growth factor (HB-E
Publikováno v:
Kidney international
The kidney clears numerous solutes from the plasma; however, retention of these solutes causes uremic illness when the kidneys fail. We know remarkably little about which retained solutes are toxic and this limits our ability to improve dialysis ther
Publikováno v:
Kidney International
Kidney International, Nature Publishing Group, 2013, 83 (4), pp.674-683. ⟨10.1038/ki.2012.478⟩
Kidney International, Nature Publishing Group, 2013, 83 (4), pp.674-683. ⟨10.1038/ki.2012.478⟩
Sodium depletion has a protective effect on target-organ damage in hypertension independent of blood pressure. Here we tested whether chronic dietary sodium restriction may prevent the development of renal alterations associated with insulin resistan
Autor:
Mihwa Kim, Vivette D. D'Agati, Sang Won Park, Kevin M. Brown, H. Thomas Lee, Joo Yun Kim, Volker H. Haase
Publikováno v:
Kidney international
Renal ischemia-reperfusion injury is a major cause of acute kidney injury. We previously found that renal A(1) adenosine receptor (A(1)AR) activation attenuated multiple cell death pathways including necrosis, apoptosis, and inflammation. Here, we te
Autor:
Junghyun Kim, Travis D. Hull, Edgar A. Jaimes, Anupam Agarwal, Abolfazl Zarjou, Amie M. Traylor, Fady M. Mikhail, James F. George, Subhashini Bolisetty
Publikováno v:
Kidney International. 82:278-291
Heme oxygenase-1 (HO-1) catalyzes the rate-limiting step in heme degradation, producing equimolar amounts of carbon monoxide, iron, and biliverdin. Induction of HO-1 is a beneficial response to tissue injury in diverse animal models of diseases inclu
Publikováno v:
Kidney international
Corin is a protease that activates atrial natriuretic peptide, a cardiac hormone important in the control of blood pressure and salt–water balance. Here we examined the role of corin in regulating blood pressure and sodium homeostasis upon dietary