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Autor:
Sho Hasegawa, Junken Aoki, Kentaro Yoshioka, Kensuke Kojima, Tsuyoshi Inoue, Takashi Shimada, Masaomi Nangaku, Yoko Ono, Reiko Inagi, Yuko Ube, Yosuke Hirakawa, Makoto Kurano, Yutaka Yatomi, Taiga Iwama, Kuniyuki Kano
Publikováno v:
Kidney International. 101:510-526
Some patients with diabetic kidney disease (DKD) show a fast progression of kidney dysfunction and are known as a "fast decliner" (FD). Therefore, it is critical to understand pathomechanisms specific for fast decline. Here, we performed a comprehens
Autor:
Katherine Xu, Krzysztof Kiryluk
Publikováno v:
Kidney International. 101:447-450
Autor:
Michael J. Randles, Rachel Lennon, Anton Page, Charles D. Pusey, A Blease, Thomas Nicol, Sara Falcone, Elizabeth M. Angus, Paul Potter, Frederick W.K. Tam
Publikováno v:
Kidney International. 101:527-540
Nephrotic syndrome is characterized by severe proteinuria, hypoalbuminaemia, edema and hyperlipidaemia. Genetic studies of nephrotic syndrome have led to the identification of proteins playing a crucial role in slit diaphragm signaling, regulation of
Autor:
Koichiro Kato, Keiko Taguchi, Satoru Takahashi, Akihito Otsuki, Masayuki Yamamoto, Ritsuko Shimizu, Akane Yumoto, Yuma Iwamura, Takafumi Suzuki, Masaki Shirakawa, Akira Uruno, Taku Nakai, Mikiko Suzuki, Risa Okada, Daisuke Saigusa, Norio Suzuki, Dai Shiba
Publikováno v:
Kidney International. 101:92-105
Space travel burdens health by imposing considerable environmental stress associated with radioactivity and microgravity. In particular, gravity change predominantly impacts blood pressure and bone homeostasis, both of which are controlled mainly by
Autor:
Belen Ponte, Marie C. Sadler, Olivier Devuyst, Peter Vollenweider, Caroline Hayward, Zoltán Kutalik, Sandosh Padmanabhan, Eric Olinger, Murielle Bochud
Publikováno v:
Kidney International. 100:1282-1291
UMOD variants associated with higher levels of urinary uromodulin (uUMOD) increase the risk of chronic kidney disease (CKD) and hypertension. However, uUMOD levels also reflect functional kidney tubular mass in observational studies, questioning the
Autor:
Sophie Candon, Dominique Guerrot, Charlotte Laurent, Olivier Boyer, Véronique Lemée, Dorian Nezam, Isabelle Etienne, Jean-Christophe Plantier, Julie Lamulle, M. Hanoy, Mathilde Lemoine, Mouad Hamzaoui, Frank Le Roy, Ludivine Lebourg, Dominique Bertrand, Fabienne Farce
Publikováno v:
Kidney International
Autor:
Lawrence J. Appel, Harold I. Feldman, Rupal Mehta, Santosh L. Saraf, Jiang He, Mahboob Rahman, Jing Chen, Monique E. Cho, Xuan Cai, Tamara Isakova, Robert G. Nelson, Panduranga S. Rao, Jongmin Lee, Mark Unruh, Vallabh O. Shah, John M. Flack, Alan S. Go, Valentin David, Tariq Shafi, Myles Wolf, James P. Lash, Raymond R. Townsend
Publikováno v:
Kidney Int
Disordered iron and mineral homeostasis are interrelated complications of chronic kidney disease that may influence cardiovascular and kidney outcomes. In a prospective analysis of 3747 participants in the Chronic Renal Insufficiency Cohort Study, we
Publikováno v:
Kidney International. 100:1190-1198
The safety and efficacy of direct-acting antiviral therapies have allowed the transplantation of organs from hepatitis C virus (HCV)-viremic donors into uninfected recipients. This novel strategy contrasts with the previous standard-of-care practice
Autor:
Yiqing Guo, Ahmed A. Attallah, Justina Henein, Xiangchen Gu, Takashi Hato, Nehaben A. Gujarati, Kathleen G. Dickman, Avi Ma'ayan, Chia-Tung Shun, Amy Zollman, Sandeep K. Mallipattu, Monica P. Revelo, Chung-Hsin Chen, John Cijiang He, Sian E. Piret, Thomas A. Rosenquist
Publikováno v:
Kidney International. 100:1250-1267
Loss of fatty acid β-oxidation (FAO) in the proximal tubule is a critical mediator of acute kidney injury and eventual fibrosis. However, transcriptional mediators of FAO in proximal tubule injury remain understudied. Krüppel-like factor 15 (KLF15)
Autor:
Travis Nemkov, Jonathan M. Beirne, Irene Gonzalez-Menendez, Lina Schaefer, Leticia Quintanilla-Martinez, Lingsi Kong, Mengyun Xiao, Daniel Essigke, Bernhard N. Bohnert, Rosi Bissinger, Anja Schork, Martin Schaller, M. Zaher Kalo, Birgit Fehrenbacher, Matthias Wörn, Kingsley Omage, Marijke Grau, Tamam Bakchoul, Angelo D'Alessandro, Achal Dhariwal, Florian Grahammer, Syed M. Qadri, Andreas L. Birkenfeld, Thomas Dietz, Ferruh Artunc
Publikováno v:
Kidney International. 100:1227-1239
Anemia is a common complication of chronic kidney disease, affecting the quality of life of patients. Among various factors, such as iron and erythropoietin deficiency, reduced red blood cell (RBC) lifespan has been implicated in the pathogenesis of