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Autor:
Sho Hasegawa, Junken Aoki, Kentaro Yoshioka, Kensuke Kojima, Tsuyoshi Inoue, Takashi Shimada, Masaomi Nangaku, Yoko Ono, Reiko Inagi, Yuko Ube, Yosuke Hirakawa, Makoto Kurano, Yutaka Yatomi, Taiga Iwama, Kuniyuki Kano
Publikováno v:
Kidney International. 101:510-526
Some patients with diabetic kidney disease (DKD) show a fast progression of kidney dysfunction and are known as a "fast decliner" (FD). Therefore, it is critical to understand pathomechanisms specific for fast decline. Here, we performed a comprehens
Autor:
Michael J. Randles, Rachel Lennon, Anton Page, Charles D. Pusey, A Blease, Thomas Nicol, Sara Falcone, Elizabeth M. Angus, Paul Potter, Frederick W.K. Tam
Publikováno v:
Kidney International. 101:527-540
Nephrotic syndrome is characterized by severe proteinuria, hypoalbuminaemia, edema and hyperlipidaemia. Genetic studies of nephrotic syndrome have led to the identification of proteins playing a crucial role in slit diaphragm signaling, regulation of
Autor:
Koichiro Kato, Keiko Taguchi, Satoru Takahashi, Akihito Otsuki, Masayuki Yamamoto, Ritsuko Shimizu, Akane Yumoto, Yuma Iwamura, Takafumi Suzuki, Masaki Shirakawa, Akira Uruno, Taku Nakai, Mikiko Suzuki, Risa Okada, Daisuke Saigusa, Norio Suzuki, Dai Shiba
Publikováno v:
Kidney International. 101:92-105
Space travel burdens health by imposing considerable environmental stress associated with radioactivity and microgravity. In particular, gravity change predominantly impacts blood pressure and bone homeostasis, both of which are controlled mainly by
Autor:
Belen Ponte, Marie C. Sadler, Olivier Devuyst, Peter Vollenweider, Caroline Hayward, Zoltán Kutalik, Sandosh Padmanabhan, Eric Olinger, Murielle Bochud
Publikováno v:
Kidney International. 100:1282-1291
UMOD variants associated with higher levels of urinary uromodulin (uUMOD) increase the risk of chronic kidney disease (CKD) and hypertension. However, uUMOD levels also reflect functional kidney tubular mass in observational studies, questioning the
Autor:
Lawrence J. Appel, Harold I. Feldman, Rupal Mehta, Santosh L. Saraf, Jiang He, Mahboob Rahman, Jing Chen, Monique E. Cho, Xuan Cai, Tamara Isakova, Robert G. Nelson, Panduranga S. Rao, Jongmin Lee, Mark Unruh, Vallabh O. Shah, John M. Flack, Alan S. Go, Valentin David, Tariq Shafi, Myles Wolf, James P. Lash, Raymond R. Townsend
Publikováno v:
Kidney Int
Disordered iron and mineral homeostasis are interrelated complications of chronic kidney disease that may influence cardiovascular and kidney outcomes. In a prospective analysis of 3747 participants in the Chronic Renal Insufficiency Cohort Study, we
Autor:
Yiqing Guo, Ahmed A. Attallah, Justina Henein, Xiangchen Gu, Takashi Hato, Nehaben A. Gujarati, Kathleen G. Dickman, Avi Ma'ayan, Chia-Tung Shun, Amy Zollman, Sandeep K. Mallipattu, Monica P. Revelo, Chung-Hsin Chen, John Cijiang He, Sian E. Piret, Thomas A. Rosenquist
Publikováno v:
Kidney International. 100:1250-1267
Loss of fatty acid β-oxidation (FAO) in the proximal tubule is a critical mediator of acute kidney injury and eventual fibrosis. However, transcriptional mediators of FAO in proximal tubule injury remain understudied. Krüppel-like factor 15 (KLF15)
Autor:
Travis Nemkov, Jonathan M. Beirne, Irene Gonzalez-Menendez, Lina Schaefer, Leticia Quintanilla-Martinez, Lingsi Kong, Mengyun Xiao, Daniel Essigke, Bernhard N. Bohnert, Rosi Bissinger, Anja Schork, Martin Schaller, M. Zaher Kalo, Birgit Fehrenbacher, Matthias Wörn, Kingsley Omage, Marijke Grau, Tamam Bakchoul, Angelo D'Alessandro, Achal Dhariwal, Florian Grahammer, Syed M. Qadri, Andreas L. Birkenfeld, Thomas Dietz, Ferruh Artunc
Publikováno v:
Kidney International. 100:1227-1239
Anemia is a common complication of chronic kidney disease, affecting the quality of life of patients. Among various factors, such as iron and erythropoietin deficiency, reduced red blood cell (RBC) lifespan has been implicated in the pathogenesis of
Publikováno v:
Kidney International. 100:1023-1036
Vitamin K, well known for its role in coagulation, encompasses 2 major subgroups: vitamin K1 is exclusively synthesized by plants, whereas vitamin K2 mostly originates from bacterial synthesis. Vitamin K serves as a cofactor for the enzyme gamma-glut
Autor:
Chun-Yu Deng, Zhiming Ye, Xia Chen, Caoshuai Dou, Yingzhen Wen, Zhiwen Lian, Wenjian Wang, Juan Hu, Sijia Li, Wei Shi, Zhuo Li, Ruizhao Li, Guibao Ke, Qianmei Zhang, Jianchao Ma, Ruyi Liao, Xueqin Chen, Lixia Xu, Ting Lin, Wei Dong, Li Zhang, Yue Du, Houqin Xiao, Yuanhan Chen, Bohou Li, Fengxia Zhang, Chaosheng He, Zhonglin Feng, Shuangshuang Zhu, Shuangxin Liu, Jie Xiao, Xingchen Zhao, Minghao Zheng, Xinling Liang, Su-Juan Kuang, Hong Zhang
Publikováno v:
Kidney International. 100:377-390
Receptor activator of NF-κB (RANK) expression is increased in podocytes of patients with diabetic nephropathy. However, the relevance of RANK to diabetic nephropathy pathobiology remains unclear. Here, to evaluate the role of podocyte RANK in the de
Autor:
Johannes Loffing, Robert Little, Søren Brandt Poulsen, Sathish K. Murali, Marleen L. A. Kortenoeven, Lei Cheng, Robert A. Fenton, David Penton, Vladimir V. Matchkov
Publikováno v:
Poulsen, S B, Cheng, L, Penton, D, Kortenoeven, M L A, Matchkov, V V, Loffing, J, Little, R, Murali, S K & Fenton, R A 2021, ' Activation of the kidney sodium chloride cotransporter by the β2-adrenergic receptor agonist salbutamol increases blood pressure ', Kidney International, vol. 100, no. 2, pp. 321-335 . https://doi.org/10.1016/j.kint.2021.04.021
The thiazide-sensitive sodium-chloride-cotransporter (NCC) in the kidney distal convoluted tubule (DCT) plays an essential role in sodium and potassium homeostasis. Here, we demonstrate that NCC activity is increased by the β2-adrenoceptor agonist s