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Publikováno v:
Kidney Int
APOL1 kidney risk variants (RVs) were identified in 2010 as major drivers of glomerular, tubulointerstitial and renal microvascular disease in individuals with sub-Saharan African ancestry. In December 2020, the “APOL1 at Ten” conference summariz
Publikováno v:
Kidney International. 99:1077-1087
It is well known that innate immune cells, including dendritic cells, macrophages, and natural killer cells, contribute to pathogenesis and protection in various kidney diseases. The understanding of innate immunity has been advanced recently by the
Autor:
Agnes B. Fogo
Publikováno v:
Kidney International. 100:978-980
Podocyte loss is a key element underlying glomerulosclerosis. Various mechanisms have been proposed for cell loss. These include local hemodynamic effects and local stresses on cell and hemodynamic changes, which together may contribute to detachment
Publikováno v:
Kidney Int
Retinoic acid receptor responder protein 1 (RARRES1) has been identified as a novel gene for the regulation of podocyte function, and its expression is increased in glomerular disease and associated with disease progression. Increased expression of R
Autor:
Abbal Koirala, Natalya V. Kaverina, Jeffrey W. Pippin, Shreeram Akilesh, Diana G. Eng, Carol Loretz, Yuliang Wang, Stuart J. Shankland
Publikováno v:
Kidney Int
Glomerular podocytes undergo structural and functional changes with advanced age, that increase susceptibility of aging kidneys to worse outcomes following superimposed glomerular diseases. To delineate transcriptional changes in podocytes in aged mi
Publikováno v:
Kidney Int
A revolution in cellular measurement technology is underway. Whereas prior studies have been able to analyze only the averaged outputs from renal tissue, we now can accurately monitor genome-wide gene expression, regulation, function, cellular histor
Autor:
Mingyu Liang, Anna Marie Williams
Publikováno v:
Kidney International. 98:275-277
microRNAs play prominent regulatory roles by inducing target mRNA degradation or translational repression. Several studies have highlighted the power of microRNAs as biomarkers and potential mechanistic mediators of human kidney disease. Small RNA de
Autor:
Hiroshi Nishi
Publikováno v:
Kidney Int
Wnt/β-catenin signaling is essential in the pathogenesis of renal fibrosis. We previously reported inhibition of the Wnt O-acyl transferase porcupine, required for Wnt secretion, dramatically attenuates kidney fibrosis in the murine unilateral urete
Publikováno v:
Kidney International. 95:760-773
Tissue macrophages are crucial players in homeostasis, inflammation, and immunity. They are characterized by heterogeneity and plasticity, due to which they display a continuum of phenotypes with M1/M2 presenting 2 extremes of this continuum. M2 macr
Autor:
Andres A. Urrutia, Malini Rajan, Jiao Liu, Volker H. Haase, Olena Davidoff, Hanako Kobayashi, Mikhail Burmakin, Ken Ishii, Zubaida Saifudeen
Publikováno v:
Kidney International. 92:1370-1383
Hypoxia in the embryo is a frequent cause of intra-uterine growth retardation, low birth weight, and multiple organ defects. In the kidney, this can lead to low nephron endowment, predisposing to chronic kidney disease and arterial hypertension. A ke