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Autor:
Christian Hugo, Linda Hickmann, Vladimir T. Todorov, R. Ariel Gomez, Jan Sradnick, Maria Luisa S. Sequeira-Lopez, Moath Al-Mekhlafi, Michael Gerlach, Peter Lachmann, Bernd Hohenstein, Anne Steglich
Publikováno v:
Kidney International. 92:1419-1432
Renin lineage cells (RLCs) serve as a progenitor cell reservoir during nephrogenesis and after renal injury. The maintenance mechanisms of the RLC pool are still poorly understood. Since RLCs were also identified as a progenitor cell population in bo
Autor:
Jürgen Floege
Publikováno v:
Kidney International. 93:542-544
The diagnosis of IgA nephropathy relies on the histologic demonstration of glomerular mesangial IgA deposits. However, only a very small fraction of IgA, namely, galactose-deficient IgA1, seems to induce the disease. So far, this type of IgA could on
Publikováno v:
Kidney International. 86:738-746
In vitro and ex vivo studies have elucidated the step-by-step process whereby some physicochemically abnormal light chains are processed by mesangial cells to form amyloid fibrils. Although crucial steps in the cascade of events have been determined,
Autor:
Masakazu Fujii, Shuji Sasaki, Kunihisa Kobayashi, Ryoichi Takayanagi, Yasutaka Maeda, Toyoshi Inoguchi, Jing Zheng
Publikováno v:
Kidney International. 78(9):905-919
We recently found a markedly lower prevalence of vascular complications, including kidney disease, in diabetic patients with Gilbert syndrome, a congenital form of hyperbilirubinemia, suggesting a beneficial effect of bilirubin (BIL) on diabetic neph
Autor:
Rachel A. Craven, Rosamonde E. Banks, Jeff N. Keen, Nick Hornigold, Andrew Mooney, Timothy S. Johnson
Publikováno v:
Kidney International. 77:329-338
Glomerulosclerosis is characterized by the loss of glomerular cells by apoptosis and deposition of collagen type I into the normal collagen IV-containing mesangial matrix. We sought to determine the alterations that might contribute to these changes
Autor:
Akira Sugawara, Hideki Yokoi, Tetsuro Yoshioka, Kiyoshi Mori, Kazutomo Sawai, Masato Kasahara, Masashi Mukoyama, Y. Ogawa, Kazuwa Nakao, Yoshihiko Saito, Takayoshi Suganami, Takashige Kuwabara
Publikováno v:
Kidney International. 73(4):446-455
Connective tissue growth factor (CTGF) is a potent inducer of extracellular matrix accumulation. In diabetic nephropathy, CTGF expression is markedly upregulated both in podocytes and mesangial cells, and this may play an important role in its pathog
Autor:
Toshikatsu Shimizu, Y. Mukaida, Naonori Uozumi, Satoshi Akiba, Mayuko Oka, Takashi Sato, K. Hane
Publikováno v:
Kidney International. 70(6):1013-1018
The deposition of atherogenic lipoproteins such as oxidized low-density lipoprotein (oxLDL) within the mesangium is involved in the overproduction of extracellular matrix proteins, a key event in the progression of glomerular diseases including glome
Autor:
J.W. de Fijter, R. N. Van Der Geest, Beatrijs Oortwijn, Anja Roos, C. van Kooten, P.J.M. van der Boog, M. R. Daha
Publikováno v:
Kidney International. 69(7):1131-1138
IgA nephropathy (IgAN) is characterized by deposits of IgA in the renal mesangium. It is thought that deposits of IgA mainly involve high molecular weight (HMW) IgA1. However, there is limited information on the exact composition of HMW IgA in these
Publikováno v:
Kidney International. 69(2):248-256
Connective tissue growth factor (CTGF) is involved in mitogenesis, matrix production, and chemotaxis in mesenchymal cells. The effects of CTGF on the production of chemokines remain unclear. The present studies investigate the regulatory role of CTGF
Publikováno v:
Kidney International. 68(5):2143-2153
Up-regulation of glomerular COX-2 by angiotensin II: Role of reactive oxygen species. Background Prostaglandins such as prostaglandin E 2 (PGE 2 ) and prostaglandin I 2 (PGI 2 ) counteract the angiotensin II (Ang II)-induced vasoconstriction in the g