Zobrazeno 1 - 9
of 9
pro vyhledávání: '"James Blanchard"'
Autor:
James Blanchard, Agegnehu Gettie, Heather Knight, Susan V. Westmoreland, Ke Zhuang, Cecilia Cheng-Mayer, Lily Tsai, Ana Rachel Leda, Carole Harbison
Publikováno v:
Journal of Virology. 88:8407-8420
Human immunodeficiency virus type 1 (HIV-1) infection in the central nervous system (CNS) is characterized by replication in macrophages or brain microglia that express low levels of the CD4 receptor and is the cause of HIV-associated dementia and re
Autor:
Agegnehu Gettie, James Blanchard, Kasi E. Russell-Lodrigue, Cecilia Cheng-Mayer, Alexandra Mumbauer, Susan V. Westmoreland, Wuze Ren, Michael S. Seaman
Publikováno v:
Journal of Virology. 87:6137-6149
Most human immunodeficiency virus (HIV) transmissions are initiated with CCR5 (R5)-using viruses across mucosal surfaces, with the majority in regions where HIV type 1 (HIV-1) clade C predominates. Mucosally transmissible, highly replication competen
Autor:
Cecilia Cheng-Mayer, James Blanchard, Ke Zhuang, Susan V. Westmoreland, Silvana Tasca, Heather Knight, Agegnehu Gettie
Publikováno v:
Journal of Virology. 85:3086-3094
We recently described a coreceptor switch in rapid progressor (RP) R5 simian-human immunodeficiency virus SF162P3N (SHIV SF162P3N )-infected rhesus macaques that had high virus replication and undetectable or weak and transient antiviral antibody res
Publikováno v:
Journal of Virology. 82:5653-5656
We report here a second case of coreceptor switch in R5 simian-human immunodeficiency virus SF162P3N (SHIV SF162P3N )-infected macaque CA28, supporting the use of this experimental system to examine factors that drive the change in coreceptor prefere
Autor:
Agegnehu Gettie, James Blanchard, Siu-hong Ho, Lili Shek, Amy Li, Silvana Tasca, Daniel Boden, Cecilia Cheng-Mayer
Publikováno v:
Journal of Virology. 81:8621-8633
The basis for the switch from CCR5 to CXCR4 coreceptor usage seen in ∼50% of human immunodeficiency virus type 1 (HIV-1) subtype B-infected individuals as disease advances is not well understood. Among the reasons proposed are target cell limitatio
Autor:
James Blanchard, Cecilia Cheng-Mayer, Wuze Ren, Lily Tsai, Agegneu Gettie, Madina Shakirzyanova
Publikováno v:
Journal of virology. 86(17)
We previously reported efficient transmission of the pathogenic R5 simian-human immunodeficiency virus SHIV SF162P3N isolate in Indian rhesus macaques by intravenous and intrarectal inoculations, with a switch to CXCR4 coreceptor usage in ∼50% of i
Publikováno v:
Journal of virology. 79(19)
We used experimental infection of rhesus macaques with envelope gp120 V3 loop isogenic simian-human immunodeficiency virus (SHIV) molecular clones to more clearly define the impact of human immunodeficiency virus type 1 coreceptor usage in target cel
Autor:
Mayla Hsu, Janet M. Harouse, James Blanchard, Cecilia Cheng-Mayer, Clarisa Buckner, Agegnehu Gettie
Publikováno v:
Journal of virology. 77(2)
Through rapid serial transfer in vivo, the chimeric CCR5-tropic simian/human immunodeficiency virus SHIV SF162 evolved from a virus that is nonpathogenic and poorly transmissible across the vaginal mucosa to a variant that still maintains CCR5 usage
Autor:
Stephen M. Smith, Melissa Pope, Agegnehu Gettie, Amara Luckay, Ralf Ignatius, Preston A. Marx, James Blanchard, Ralph M. Steinman, Davorka Messmer, Christine Russo, Paul Racz, Klara Tenner-Racz
Publikováno v:
Journal of virology. 76(19)
Information on the establishment of immunodeficiency virus infection through transmission of infected cells is sparse. Dendritic cells (DCs) and T cells may be central to the onset and subsequent spread of infection following mucosal exposure. To dir