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Publikováno v:
J Virol
Viral antagonism of innate immune pathways is a common mechanism by which viruses evade immune surveillance. Infection of host cells with reovirus leads to the blockade of NF-{kappa}B, a key transcriptional regulator of the hosts innate immune respon
Autor:
Abhijit Chowdhury, Simanti Datta, Gopal Krishna Dhali, Filip Kalčic, Saikat Chakrabarti, Soma Banerjee, Rajiv Kumar Mondal, Ayana Baidya, Zlatko Janeba, Mousumi Khatun, Krishna Kumar, Ondřej Baszczyňski, Kausik S. Das
Publikováno v:
J Virol
Nucleos(t)ide analogues entecavir (ETV) and tenofovir disoproxil fumarate (TDF) are recommended as first-line monotherapies for chronic hepatitis B (CHB). Multiple HBV genotypes/subgenotypes have been described, but their impact on treatment response
Autor:
Joshua A. Acklin, Maryline Panis, Christina A Higgins, Skyler Uhl, Yaron Bram, Daniel Blanco-Melo, Benjamin R. tenOever, Benjamin E. Nilsson-Payant, Robert E. Schwartz, Ashley S. Doane, Vasuretha Chandar, Rohit Chandwani, Phillip Cohen, Brad R. Rosenberg, Adrien Grimont, Roosheel S. Patel, Olivier Elemento, Jean K. Lim
Publikováno v:
Journal of Virology
SARS-CoV-2, the etiological agent of COVID-19, is characterized by a delay in type I interferon (IFN-I)-mediated antiviral defenses alongside robust cytokine production. Here, we investigate the underlying molecular basis for this imbalance and impli
Autor:
Andrew D. Badley, Caitlin J. VanLith, Anisha Misra, Sekar Natesampillai, Ashton Krogman, Aswath P. Chandrasekar, Alecia Alto, F. N.U. Shweta, Nathan W. Cummins, Joseph D. Yao
Publikováno v:
J Virol
The antiapoptotic protein BCL2 inhibits death of HIV-infected cells. Previously, we showed that the BCL2 inhibitor venetoclax selectively kills acutely HIV-infected cells and reduces HIV DNA in latently infected CD4 T cells ex vivo after reactivation
Publikováno v:
J Virol
Small-molecule drugs inhibiting BK polyomavirus (BKPyV) represent a significant unmet clinical need in view of polyomavirus-associated nephropathy or hemorrhagic cystitis, which complicate 5% to 25% of kidney and hematopoietic cell transplantations.
Autor:
Wenjiao Wu, Shuyin Gu, Shuwen Liu, Qiao Zhang, Yingyuan Zhong, Lizhu Chen, Yilu Ye, Qi Huang, Mingkai Feng
Publikováno v:
J Virol
Guanylate-binding protein 7 (GBP7) belongs to the GBP family, which plays key roles in mediating innate immune responses to intracellular pathogens. Thus far, GBP7 has been reported to be a critical cellular factor against bacterial infection. Howeve
Publikováno v:
J Virol
AIM2 is a cytosolic DNA sensor of the inflammasome, which induces critical innate immune responses against various invading pathogens. Earlier biochemical studies showed that the binding of AIM2 to DNA triggered the self-oligomerization of AIM2, whic
Autor:
Yung-Ju Yeh, His-Yuan Huang, Hsien Da Huang, Sheng Da Hsu, Ju-Chien Cheng, Michael M. C. Lai, Ching-Ping Tseng
Publikováno v:
J Virol
MicroRNA let-7b expression is induced by infection of hepatitis C virus (HCV) and is involved in the regulation of HCV replication by directly targeting the HCV genome. The current study demonstrated that let-7b directly targets negative regulators o
Autor:
Young Ki Choi, Ju Hwan Jeong, Elena A. Govorkova, Khristine Joy C. Antigua, Min-Suk Song, Yun Hee Baek, Richard J. Webby, Won-Suk Choi
Publikováno v:
J Virol
Laninamivir (LAN) is a long-acting neuraminidase (NA) inhibitor (NAI) with a similar binding profile in the influenza NA enzyme active site as those of other NAIs, oseltamivir (OS), zanamivir (ZAN), and peramivir, and may share common resistance mark
Autor:
Fuming Zhang, Poonam Sharma, Ritesh Tandon, Joshua S. Sharp, Nicole M. Ashpole, Hao Liu, Dipanwita Mitra, Martin G. McCandless, Vitor H. Pomin, Weihua Jin, Robert J. Linhardt
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
Journal of Virology
J Virol
article-version (status) pre
article-version (number) 1
Journal of Virology
J Virol
Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) has caused a pandemic of historic proportions and continues to spread globally, with enormous consequences to human health. Currently there is no vaccine, effective therapeutic, or