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Autor:
Barbara Cellini, Paola Laurino, Gioena Pampalone, Francesca Cutruzzolà, Mirco Dindo, Giannamaria Annunziato, Silvia Grottelli, Andrea Faccini, Giorgio Giardina, Marco Pieroni, Gabriele Costantino
Publikováno v:
Journal of Urology. 203:876-877
Peroxisomal alanine:glyoxylate aminotransferase (AGT) is responsible for glyoxylate detoxification in human liver and utilizes pyridoxal 5′-phosphate (PLP) as coenzyme. The deficit of AGT leads to Primary Hyperoxaluria Type I (PH1), a rare disease
Autor:
Debleena Ray, Wei Kiang Lim, Mei Wang, Patrick J. Casey, Sujoy Ghosh, Suhail Ahmed Kabeer Rasheed, Xiaoran Chai
Publikováno v:
J Biol Chem
GNA13, the α subunit of a heterotrimeric G protein, mediates signaling through G-protein–coupled receptors (GPCRs). GNA13 is up-regulated in many solid tumors, including prostate cancer, where it contributes to tumor initiation, drug resistance, a
Publikováno v:
Journal of Urology. 190:1421-1429
The requirement of integrins for mechanotransduction has been recognized for some time. We investigated the role of integrin subunits and their pathway in the physiological stretch induced contractility and proliferation of human bladder smooth muscl
Publikováno v:
Journal of Urology. 188:661-667
A mechanical stimulus on detrusor tissue is critical to bladder outlet obstruction progression and functional bladder tissue engineering. A hypothesis is that mechanical stimulus triggers human bladder smooth muscle cell proliferation. To help better
Autor:
Takuya Koie, Hayato Yamamoto, Shigeru Tsuboi, Mihoko Sutoh, Shingo Hatakeyama, Takahiro Yoneyama, Hisao Saitoh, Tomihisa Funyu, Chikara Ohyama, Kanemitsu Yamaya, Toshiya Nakamura, Yasuhiro Hashimoto
Publikováno v:
Journal of Urology. 185:1930-1938
Invadopodia (protrusions of the plasma membrane formed by invasive tumor cells) have an essential role in bladder tumor invasion. To understand the process of bladder tumor invasion it is crucial to investigate the molecular mechanisms of invadopodia
Publikováno v:
Journal of Urology. 185:1504-1512
Metastasis cell adhesion molecule/MUC18, a cell adhesion molecule in the Ig-like gene super family, is a key determinant in prostate cancer cell progression. However, the mechanisms by which human metastasis cell adhesion molecule/MUC18 stimulates pr
Autor:
Craig Niederberger
Publikováno v:
Journal of Urology. 191:1354-1356
Autor:
Niyas Kudukkil Pulloor, Neha Dikshit, Christelle En Lin Chua, Pradeep Bist, Marci A. Scidmore, Bor Luen Tang, Bindu Sukumaran, Swaine L. Chen, Jason A. Carlyon, Shannon N. Fenlon
Publikováno v:
PLoS Pathogens, Vol 11, Iss 8, p e1005083 (2015)
PLoS Pathogens
PLoS Pathogens
Recurrent urinary tract infections (UTIs) caused by uropathogenic E. coli (UPEC) are common and morbid infections with limited therapeutic options. Previous studies have demonstrated that persistent intracellular infection of bladder epithelial cells
Publikováno v:
Journal of Urology. 183:2409-2418
Androgen refractory prostate cancer is a major clinical challenge. Treatment approaches to prostate cancer are based on various mechanisms that cause malignant cell apoptosis. Of these strategies the anticancer effect of triggering death receptors is
Publikováno v:
Journal of Urology. 190:1645-1647