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Autor:
Redouane Rouas, Oberdan Leo, Philippe Martiat, Bassam Badran, Jean-Christophe Verougstraete, Philippe Lewalle, Pedro Romero, Arsène Burny, Fadi Jebbawi, Makram Merimi, Hussein Fayyad-Kazan
Publikováno v:
Journal of translational medicine, vol. 12, pp. 218
Journal of translational medicine, 12 (1
Journal of Translational Medicine
Journal of translational medicine, 12 (1
Journal of Translational Medicine
Background: Recently, regulatory T (Treg) cells have gained interest in the fields of immunopathology, transplantation and oncoimmunology. Here, we investigated the microRNA expression profile of human natural CD8+CD25+ Treg cells and the impact of m
Autor:
Yvon Lebranchu, Frédéric Dehaut, Laurence Martin, Florence Velge-Roussel, Valérie Chabot, Daniel Meley, Luc Sensebé, Christophe Baron
Publikováno v:
Journal of Translational Medicine
Journal of Translational Medicine, 2016, 14 (1), pp.93. ⟨10.1186/s12967-016-0848-2⟩
Journal of Translational Medicine, BioMed Central, 2016, 14 (1), pp.93. ⟨10.1186/s12967-016-0848-2⟩
Journal of Translational Medicine, 2016, 14 (1), pp.93. ⟨10.1186/s12967-016-0848-2⟩
Journal of Translational Medicine, BioMed Central, 2016, 14 (1), pp.93. ⟨10.1186/s12967-016-0848-2⟩
International audience; Background: An efficient strategy for programing dendritic cells (DCs) for cancer immunotherapy is the optimiza‑ tion of their maturation so that they can efficiently stimulate cancer‑specific T cell responses. Interleukin
Autor:
Ahmed Hachem, Rahma Boulahya, Haissam Abou-Saleh, Lara Bou Khzam, Yahye Merhi, Olivier Bouchereau, Younes Zaid
Publikováno v:
Journal of Translational Medicine
Background Endothelial progenitor cells (EPCs) have been implicated in neoangiogenesis, endothelial repair and cell-based therapies for cardiovascular diseases. We have previously shown that the recruitment of EPCs to sites of vascular lesions is fac
Publikováno v:
Journal of Translational Medicine
Background Induced pluripotent stem cells (iPSC) possess an enormous potential as both, scientific and therapeutic tools. Their application in the regenerative medicine provides new treatment opportunities for numerous diseases, including type 1 diab
Autor:
Garif Yalak, Bjorn R. Olsen
Publikováno v:
Journal of Translational Medicine
Summary Recent advances in extracellular signaling suggest that extracellular protein phosphorylation is a regulatory mechanism outside the cell. The list of reported active extracellular protein kinases and phosphatases is growing, and phosphorylati
Autor:
Vicky Fan, Hilary M. Sheppard, Daniel Verdon, Alicia J. Didsbury, Natalie Lorenz, P. Rod Dunbar, Yu-Yu Joyce Ho, Nigel P. Birch, Vaughan Feisst, Anna E. S. Brooks
Publikováno v:
Journal of Translational Medicine
Background microRNAs (miRNAs) are emerging as key regulators of the immune system, but their role in CD8+ T cell differentiation is not well explored. Some evidence suggests that signals from cell surface receptors influence the expression of miRNAs
Publikováno v:
Journal of Translational Medicine
The mesenchymal stem cell (MSC) is being broadly studied in clinical trials. Contrary to the early paradigm of cell replacement and differentiation as a therapeutic mechanism of action, evidence is mounting that the secretions of the cells are respon
Autor:
Ye. V. Parfyonova, A. A. Karpenko, Alexander I. Shevchenko, E. A. Pokushalov, M. K. Zhiven, E. Aboian, Ludmila N. Ivanova, Anton Strunov, Suren M. Zakian, Sh. B. Saaya, A. M. Smirnova, Pavel I. Makarevich, Irina S. Zakharova
Publikováno v:
Journal of Translational Medicine
Background Endothelial and smooth muscle cells are considered promising resources for regenerative medicine and cell replacement therapy. It has been shown that both types of cells are heterogeneous depending on the type of vessels and organs in whic
Autor:
Giuseppe Grandaliano, Federica Rascio, Barbara Infante, Adelaide Di Lorenzo, Giovanni Stallone, Gianluigi Zaza
Publikováno v:
Journal of Translational Medicine
The mammalian target of rapamycin (mTOR), a cytoplasmic serine/threonine kinase, represents a key biologic "switch" modulating cell metabolisms in response to environmental signals and is now recognized as a central regulator of the immune system. Th
Autor:
Yunpeng Zhao, Shuai-Shuai Wang, Hua Zhao, Yuanqiang Zhang, Lin Nie, Lei Cheng, Yi Liu, Xiaoqing Wang, Jingkun Li
Publikováno v:
Journal of Translational Medicine
Background Low back pain and sciatica caused by intervertebral disc (IVD) disease are associated with inflammatory responses. The cytokine interleukin 17 (IL-17) is elevated in herniated and degenerated IVD tissues and acts as a regulator of disc inf