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pro vyhledávání: ''
Autor:
Anna Morabito, Beatrice Dozin, Barbara Banelli, Gianluigi Lunardi, Alessia D'Alonzo, Silvia Boero, Maria Pia Pistillo, Roberta Carosio, Alessia Levaggi, Sandra Salvi, Massimo Romani, Lucia Del Mastro, Francesca Poggio, Sonia Lastraioli, Alessandro Poggi, Patrizia Piccioli, Barbara Cardinali
Publikováno v:
Journal of Translational Medicine
Background Trastuzumab is a humanized monoclonal antibody (mAb) currently used for the treatment of breast cancer (BC) patients with HER-2 overexpressing tumor subtype. Previous data reported the involvement of FcγRIIIA/IIA gene polymorphisms and/or
Autor:
Arthur Chun-Chieh Shih, You-Chin Lin, Alice L. Yu, Guo-Shiou Liao, Wen-Hsiung Li, Tan-Chi Fan, Jyh-Cherng Yu, Chih-Hao Chang
Publikováno v:
Journal of Translational Medicine
Journal of translational medicine, vol 12, iss 1
Journal of translational medicine, vol 12, iss 1
Background The major cancer related mortality is caused by metastasis and invasion. It is important to identify genes regulating metastasis and invasion in order to curtail metastatic spread of cancer cells. Methods This study investigated the associ
Autor:
Halfter, Kathrin, Hoffmann, Oliver, Ditsch, Nina, Ahne, Mareike, Arnold, Frank, Paepke, Stefan, Grab, Dieter, Bauerfeind, Ingo, Mayer, Barbara
Publikováno v:
Journal of Translational Medicine
Background Targeted anti-HER2 therapy has greatly improved the prognosis for many breast cancer patients. However, treatment for HER2 negative disease is currently still selected from a multitude of untargeted chemotherapeutic treatment options. A pr
Autor:
Mohammad Ilyas, Jennifer M. Eremin, Chandan Verma, Oleg Eremin, Gerard P Cowley, Viriya Kaewkangsadan, Mohamed El-Sheemy
Publikováno v:
Journal of Translational Medicine
Background NK cells contribute to tumour surveillance, inhibition of growth and dissemination by cytotoxicity, secretion of cytokines and interaction with immune cells. Their precise role in human breast cancer is unclear and the effect of therapy po
Publikováno v:
Journal of Translational Medicine
HOTAIR plays an important role in the regulation of cancer cell proliferation and cancer invasion in breast cancer. The up-regulation of HOTAIR has been reported in both estrogen receptor (ER) positive and triple-negative (TN) breast cancer. It has b
Autor:
Linda L. Garland, H-H. Sherry Chow, Chiu Hsieh Hsu, Catherine A. Cordova, Terri L. Cornelison, Wade M. Chew, Valerie D. Butler, Brandy M. Heckman-Stoddard
Publikováno v:
Journal of Translational Medicine
Breast cancer risk is partially determined by several hormone-related factors. Preclinical and clinical studies suggested that resveratrol may modulate these hormonal factors. We conducted a pilot study in postmenopausal women with high body mass ind
Publikováno v:
Journal of Translational Medicine
Background Gadd45a is a member of the Gadd45 family of genes that are known stress sensors. Gadd45a has been shown to serve as an effector in oncogenic stress in breast carcinogenesis in murine models. The present study was aimed at clarifying the ex
Autor:
Yi-Teng Huang, Xiao-Xuan Zheng, Yuping Chen, Zhou Li, Zongtai Li, Fei-Fei Li, Xiao-Fang Zou, Hao Zhang, Chen Ke
Publikováno v:
Journal of Translational Medicine
Background Protein Tyrosine Phosphatase Receptor-type O (PTPRO) has recently been in the spotlight as a tumor suppressor, whose encoding gene is frequently methylated in cancers. We examined the methylation status of the PTPRO gene promoter in breast
Publikováno v:
Journal of Translational Medicine
Background Axillary node staging plays an important role in the prognostic evaluation and planning of adjuvant treatment. Breast cancer stem cells, identified on the basis of CD44+CD24-/low expression, are associated with metastases and drug resistan
Autor:
Aleksandra Markiewicz, Janusz Jaśkiewicz, Jolanta Szade, Wojciech Biernat, Marzena Wełnicka-Jaśkiewicz, Jarosław Skokowski, Tomasz Ahrends, Anna J. Żaczek, Barbara Seroczyńska
Publikováno v:
Journal of Translational Medicine
Journal of Translational Medicine, Vol 10, Iss 1, p 226 (2012)
Journal of Translational Medicine, Vol 10, Iss 1, p 226 (2012)
Background Breast cancers are phenotypically and genotypically heterogeneous tumors containing multiple cancer cell populations with various metastatic potential. Aggressive tumor cell subpopulations might more easily be captured in lymph nodes metas