Zobrazeno 1 - 10
of 12
pro vyhledávání: ''
Autor:
Arthur Chun-Chieh Shih, You-Chin Lin, Alice L. Yu, Guo-Shiou Liao, Wen-Hsiung Li, Tan-Chi Fan, Jyh-Cherng Yu, Chih-Hao Chang
Publikováno v:
Journal of Translational Medicine
Journal of translational medicine, vol 12, iss 1
Journal of translational medicine, vol 12, iss 1
Background The major cancer related mortality is caused by metastasis and invasion. It is important to identify genes regulating metastasis and invasion in order to curtail metastatic spread of cancer cells. Methods This study investigated the associ
Autor:
Mohammad Ilyas, Jennifer M. Eremin, Chandan Verma, Oleg Eremin, Gerard P Cowley, Viriya Kaewkangsadan, Mohamed El-Sheemy
Publikováno v:
Journal of Translational Medicine
Background NK cells contribute to tumour surveillance, inhibition of growth and dissemination by cytotoxicity, secretion of cytokines and interaction with immune cells. Their precise role in human breast cancer is unclear and the effect of therapy po
Publikováno v:
Journal of Translational Medicine
Liver metastasis is a frequent occurrence in patients with breast cancer; however, the available treatments are limited and ineffective. While liver-specific homing of breast cancer cells is an important feature of metastasis, the formation of liver
Publikováno v:
Journal of Translational Medicine
HOTAIR plays an important role in the regulation of cancer cell proliferation and cancer invasion in breast cancer. The up-regulation of HOTAIR has been reported in both estrogen receptor (ER) positive and triple-negative (TN) breast cancer. It has b
Autor:
Linda L. Garland, H-H. Sherry Chow, Chiu Hsieh Hsu, Catherine A. Cordova, Terri L. Cornelison, Wade M. Chew, Valerie D. Butler, Brandy M. Heckman-Stoddard
Publikováno v:
Journal of Translational Medicine
Breast cancer risk is partially determined by several hormone-related factors. Preclinical and clinical studies suggested that resveratrol may modulate these hormonal factors. We conducted a pilot study in postmenopausal women with high body mass ind
Publikováno v:
Journal of Translational Medicine
Background Gadd45a is a member of the Gadd45 family of genes that are known stress sensors. Gadd45a has been shown to serve as an effector in oncogenic stress in breast carcinogenesis in murine models. The present study was aimed at clarifying the ex
Publikováno v:
Journal of Translational Medicine
Background Axillary node staging plays an important role in the prognostic evaluation and planning of adjuvant treatment. Breast cancer stem cells, identified on the basis of CD44+CD24-/low expression, are associated with metastases and drug resistan
Autor:
Aleksandra Markiewicz, Janusz Jaśkiewicz, Jolanta Szade, Wojciech Biernat, Marzena Wełnicka-Jaśkiewicz, Jarosław Skokowski, Tomasz Ahrends, Anna J. Żaczek, Barbara Seroczyńska
Publikováno v:
Journal of Translational Medicine
Journal of Translational Medicine, Vol 10, Iss 1, p 226 (2012)
Journal of Translational Medicine, Vol 10, Iss 1, p 226 (2012)
Background Breast cancers are phenotypically and genotypically heterogeneous tumors containing multiple cancer cell populations with various metastatic potential. Aggressive tumor cell subpopulations might more easily be captured in lymph nodes metas
Autor:
Celina Ansari, Robert J Knebel, Heike E. Daldrup-Link, Magnus Johansson, Verena Reinhart, Akhilesh K. Sista, Fergus V. Coakley, Sidhartha Tavri, Sirish Kishore, Lisa M. Coussens, David G. DeNardo, Sophie Boddington
Publikováno v:
Journal of Translational Medicine
Journal of Translational Medicine, Vol 7, Iss 1, p 94 (2009)
Journal of Translational Medicine, Vol 7, Iss 1, p 94 (2009)
Purpose Peri-tumoral inflammation is a common tumor response that plays a central role in tumor invasion and metastasis, and inflammatory cell recruitment is essential to this process. The purpose of this study was to determine whether injected fluor
Autor:
Xiao Xia Huang, Ding Zhun Liao, Man Bo Cai, Jia Xing Zhang, Yi Ji Liao, Dong Qian, Jie Wei Chen, Ma Yan Huang, Shi Juan Mai, Hai Xia Deng, Yi Xin Zeng, Zhu Ting Tong, Dan Xie
Publikováno v:
Journal of Translational Medicine
Journal of Translational Medicine, Vol 10, Iss 1, p 242 (2012)
Journal of Translational Medicine, Vol 10, Iss 1, p 242 (2012)
Background The secretory small GTPase Rab27b was recently identified as an oncogene in breast cancer (BC) in vivo and in vitro studies. This research was designed to further explore the clinical and prognostic significance of Rab27B in BC patients. M