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Autor:
Anna Morabito, Beatrice Dozin, Barbara Banelli, Gianluigi Lunardi, Alessia D'Alonzo, Silvia Boero, Maria Pia Pistillo, Roberta Carosio, Alessia Levaggi, Sandra Salvi, Massimo Romani, Lucia Del Mastro, Francesca Poggio, Sonia Lastraioli, Alessandro Poggi, Patrizia Piccioli, Barbara Cardinali
Publikováno v:
Journal of Translational Medicine
Background Trastuzumab is a humanized monoclonal antibody (mAb) currently used for the treatment of breast cancer (BC) patients with HER-2 overexpressing tumor subtype. Previous data reported the involvement of FcγRIIIA/IIA gene polymorphisms and/or
Autor:
Li Li, Wei Wang, Hong Pan, Xinyi Shi, Qiang Ding, Xiaoan Liu, Ge Ma, Wenbin Zhou, Hui Xie, Shui Wang
Publikováno v:
Journal of Translational Medicine
Background Minimally invasive therapies, such as microwave ablation (MWA), are widely used for the treatment of solid tumors. Previous studies suggest that MWA is feasible for the treatment of small breast cancer, and thermal ablation may induce adap
Publikováno v:
Journal of Translational Medicine
HOTAIR plays an important role in the regulation of cancer cell proliferation and cancer invasion in breast cancer. The up-regulation of HOTAIR has been reported in both estrogen receptor (ER) positive and triple-negative (TN) breast cancer. It has b
Publikováno v:
Journal of Translational Medicine
Background Gadd45a is a member of the Gadd45 family of genes that are known stress sensors. Gadd45a has been shown to serve as an effector in oncogenic stress in breast carcinogenesis in murine models. The present study was aimed at clarifying the ex
Autor:
Yi-Teng Huang, Xiao-Xuan Zheng, Yuping Chen, Zhou Li, Zongtai Li, Fei-Fei Li, Xiao-Fang Zou, Hao Zhang, Chen Ke
Publikováno v:
Journal of Translational Medicine
Background Protein Tyrosine Phosphatase Receptor-type O (PTPRO) has recently been in the spotlight as a tumor suppressor, whose encoding gene is frequently methylated in cancers. We examined the methylation status of the PTPRO gene promoter in breast
Autor:
Jenny Brändstedt, Donal J. Brennan, Maria Alvarado-Kristensson, Björn Nodin, Jonas Manjer, Darran P. O'Connor, Fredrik Pontén, Åsa Ehlén, Jakob Eberhard, Mathias Uhlén, Karin Jirström, Ian B Jeffrey
Publikováno v:
Journal of Translational Medicine, Vol 8, Iss 1, p 78 (2010)
Journal of Translational Medicine
Journal of Translational Medicine
Background We recently demonstrated that increased expression of the RNA-binding protein RBM3 is associated with a favourable prognosis in breast cancer. The aim of this study was to examine the prognostic value of RBM3 mRNA and protein expression in
Autor:
Xiao Xia Huang, Ding Zhun Liao, Man Bo Cai, Jia Xing Zhang, Yi Ji Liao, Dong Qian, Jie Wei Chen, Ma Yan Huang, Shi Juan Mai, Hai Xia Deng, Yi Xin Zeng, Zhu Ting Tong, Dan Xie
Publikováno v:
Journal of Translational Medicine
Journal of Translational Medicine, Vol 10, Iss 1, p 242 (2012)
Journal of Translational Medicine, Vol 10, Iss 1, p 242 (2012)
Background The secretory small GTPase Rab27b was recently identified as an oncogene in breast cancer (BC) in vivo and in vitro studies. This research was designed to further explore the clinical and prognostic significance of Rab27B in BC patients. M
Autor:
Yangyu Zhao, Belinda Willard, Xiaofeng Lv, Yijing Ma, Hui Ren, Wen bing Sun, Jinge Kong, Chenguang Niu, Lemin Zheng, Fangzhu Yu, Baoqi Yu, Bing Pan, Youyi Zhang, Yubin He
Publikováno v:
Journal of Translational Medicine, Vol 10, Iss 1, p 65 (2012)
Journal of Translational Medicine
Journal of Translational Medicine
Background Previous studies suggest that oxidative stress plays an important role in the development of breast cancer. There is a significant inverse relationship between HDL and the risk and mortality of breast cancer. However, it is well known that