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Autor:
Philippe Gabriel Steg, Marc Cohen, Deepak L. Bhatt, Francesco Franchi, Dominick J. Angiolillo, Heather M Judge, Marc P. Bonaca, Marc S. Sabatine, Rangasamy Muthusamy, Fabiana Rollini, Robert F. Storey, Eugene Braunwald, Arif J. Ahsan, Mark R Thomas, Julia F Kuder
Publikováno v:
Journal of the American College of Cardiology. 67:1145-1154
Background The PEGASUS-TIMI 54 (Prevention of Cardiovascular Events in Patients with Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin–Thrombolysis In Myocardial Infarction 54) trial studied 2 doses of ticagrelor, 9
Autor:
Ronald M. Witteles, Kelly Matsuda, David P. Kao, Donald Schreiber, Randall H. Vagelos, Dianne Christopherson, Michael B. Fowler
Publikováno v:
Journal of the American College of Cardiology. 50:1835-1840
Objectives Our purpose was to evaluate the impact of nesiritide on renal function in patients with acute decompensated heart failure and baseline renal dysfunction. Background Although nesiritide is approved for the treatment of acute decompensated h
Autor:
Ying Zhu, Barry H. Greenberg, Ignatius Thomas, Barry M. Massie, Barry Ticho, Steven Goldman, William T. Abraham, Dorothy Banish, Edward P. Havranek
Publikováno v:
Journal of the American College of Cardiology. 50(7):600-606
Effects of Multiple Oral Doses of an A1 Adenosine Antagonist, BG9928, in Patients With Heart Failure: Results of a Placebo-Controlled, Dose-Escalation StudyBarry Greenberg, Ignatius Thomas, Dorothy...
Autor:
Robert A. Kloner, Graham Jackson, Malcolm I. Mitchell, Jonathan Denne, Adolph M. Hutter, Jeffrey T. Emmick
Publikováno v:
Journal of the American College of Cardiology. 42(10):1855-1860
ObjectivesThis study was designed to determine the time course of nitrate interaction with tadalafil, a phosphodiesterase 5 (PDE5) inhibitor with a half-life (t1/2) of 17.5 h.BackgroundThe PDE5 inhibitors augment the blood pressure (BP)-lowering effe
Publikováno v:
Journal of the American College of Cardiology. 61(10)
To evaluate the effects of the anticoagulant betrixaban on individual heart rate-corrected QT (QTcI).Ninety-six healthy adults were randomly assigned to single-dose betrixaban 80 and 140 mg (therapeutic and supratherapeutic doses, respectively), plac
Autor:
Denis Garceau, David D. Waters
Publikováno v:
Journal of the American College of Cardiology. 21:964-970
Objectives. The efficacy and safety of clentiazem were assessed in 199 patients with stable angina in a dose-ranging, placebocontrolled, double-blind, parallel design study. Background. To date, this is the first large efficacy and safety study of cl
Autor:
Manfred Steiner, Christian M. Heesch, Eric J. Eichhorn, Richard W. Snyder, Joy Ashcraft, Paul A. Grayburn, Donald D. Mclntire, Brian H. Negus, Jose A. Hernandez
Publikováno v:
Journal of the American College of Cardiology. 25(2)
A temporal relation has been established between cocaine ingestion and acute myocardial infarction. Based on in vitro data, an increase in platelet aggregation has been hypothesized as a factor contributing to ischemic events following cocaine abuse.
Autor:
Mauricio B. Rosenbaum, Marcelo V. Elizari, Julio O. Lázzari, Alejandro H. Haedo, Pablo A. Chiale, Jorge D. Bandieri
Publikováno v:
Journal of the American College of Cardiology. 7(5):1114-1120
The antiarrhythmic effects of verapamil, 17-monochloracetylajmaline, mexiletine and amiodarone were compared in 14 patients with chagasic myocarditis. Drugs and placebo were administered orally in the following order: placebo and verapamil, placebo a
Autor:
David J. Webb, J. Andrew Sutton, Maria Wulff, Gary J. Muirhead, Roberto Levi, Wallace W. Dinsmore
Publikováno v:
Journal of the American College of Cardiology. (1):25-31
OBJECTIVEWe sought to study the effects of a single oral dose of sildenafil citrate (50 mg) on blood pressure (BP) in men taking the nitric oxide (NO) donor drugs isosorbide mononitrate (ISMN) or glyceryl trinitrate (GTN) for stable angina.BACKGROUND
Publikováno v:
Journal of the American College of Cardiology. (15):1607-1610
ObjectivesWe tested the hypothesis that enalaprilat induces preconditioning (PC)-mimetic actions in patients with stable coronary artery disease.BackgroundAngiotensin-converting enzyme (ACE) inhibitors increase the bioavailability of bradykinin, whic