Zobrazeno 61 - 70
of 125
pro vyhledávání: '"35"'
Publikováno v:
Journal of the American Chemical Society. 120:1124-1132
A disulfide-bridged two-stranded α-helical coiled-coil peptide has been designed which undergoes a random coil to α-helical transition at pH 7 and 20 °C upon metal binding to two sites engineered into the molecule. The metal binding coiled-coil, d
Publikováno v:
Journal of the American Chemical Society. 119:12192-12200
The two available crystallographic structures of cobalamin dependent enzymes, the 27 kDa fragment of the methylcobalamin-dependent enzyme, methionine synthase, from Escherichia coli [Drennan, C. L. et al. Science 1994, 266, 1669] and the 5‘-deoxyad
Publikováno v:
Journal of the American Chemical Society. 119:9662-9671
A practical route for the total synthesis of 8,9-secokaurene diterpenes is described. The central step is the [3.3]sigmatropic rearrangement of spirocyclic intermediates such as 35, 40, and 41. All three compounds must necessarily respond identically
Publikováno v:
Journal of the American Chemical Society. 119:7440-7451
Irradiation of DNA with UV-B light causes the formation of mutagenic DNA lesions such as cis−syn and trans−syn cyclobutane pyrimidine dimers. DNA photolyases are flavin-dependent repair enzymes which directly revert the mutagenic cis−syn pyrimi
Autor:
J. Hu, Marvin J. Miller
Publikováno v:
Journal of the American Chemical Society. 119:3462-3468
A general total synthesis of mycobactins, represented by a mycobactin S, was achieved by a convergent approach. Two hydroxamic acid residues, 28 and 40b, were prepared from commercially available Nα-Cbz-l-lysine via dimethyldioxirane oxidations. Cyc
Autor:
Hariharan Venkatesan, Mark R. Barvian, Brian K. Goodman, Marc M. Greenberg, Tracy Matray, Gary P. Cook, and Christopher Tronche
Publikováno v:
Journal of the American Chemical Society. 119:1828-1839
5,6-Dihydrothymid-5-yl (4) is generated via Norrish type I cleavage of isopropyl ketone 7. Ketone 7 was site specifically incorporated into chemically synthesized polythymidylates and an oligonucleotide containing all four native deoxyribonucleotides
Publikováno v:
Journal of the American Chemical Society. 135(26)
The first examples of crystallographically characterizable complexes of Tb(2+), Pr(2+), Gd(2+), and Lu(2+) have been isolated, which demonstrate that Ln(2+) ions are accessible in soluble molecules for all of the lanthanides except radioactive promet
Publikováno v:
Journal of the American Chemical Society. 118:6924-6933
Computational predictions of planar tetracoordinate carbon R1R2CαLi2 arrangements in the cyclopropenyllithium dimer have now been realized experimentally in derivatives with additional chelating ligands. The dimer structures of two substituted cyclo
Autor:
Jiang-Ping Wu, Hitoshi Oinuma, John A. DeMattei, Yoshito Kishi, Wanjun Zheng, Laura R. Cook, Jingwu Duan
Publikováno v:
Journal of the American Chemical Society. 118:7946-7968
By addressing the relative stereochemistry of the four acyclic portions via organic synthesis, the complete relative stereochemistry of maitotoxin (MTX) has been established as 1B. The relative stereochemistry of the C.1−C.15 portion was elucidated
Autor:
Frank Guarnieri, Harel Weinstein
Publikováno v:
Journal of the American Chemical Society. 118:5580-5589
The application of a recently developed technique of conformational memories (Guarnieri, F.; Wilson, S. R. J. Comput. Chem. 1995, 16, 5, 648) to the study of peptide structure is illustrated with an analysis of the conformational populations of the d