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pro vyhledávání: '"35"'
Publikováno v:
Journal of the American Chemical Society. 141:10821-10829
High fidelity human mitochondrial DNA polymerase (Pol γ) contains two active sites, a DNA polymerization site (pol) and a 3′−5′ exonuclease site (exo) for proofreading. Although separated by 35 Å, coordination between the pol and exo sites is
Autor:
Martin J. Stillman, Thanh T. Ngu
Publikováno v:
Journal of the American Chemical Society. 128:12473-12483
The number of reported cases of chronic arsenic poisoning is on the rise throughout the world, making the study of the long-term effects of arsenic critical. As(3+) binds readily to biological thiols, including mammalian metallothionein (MT), which i
Publikováno v:
Journal of the American Chemical Society, 125(35), 10570-10579. AMER CHEMICAL SOC
The binding of a series of p-alkylbenzamidinium chloride inhibitors to the serine proteinase trypsin over a range of temperatures has been studied using isothermal titration (micro)calorimetry and molecular dynamics simulation techniques. The inhibit
Publikováno v:
Journal of the American Chemical Society. 128(24)
Simulations of hydride and deuteride transfer catalyzed by dihydrofolate reductase from the hyperthermophile Thermotoga maritima (TmDHFR) are presented. TmDHFR was modeled with its active homodimeric quaternary structure, where each monomer has three
Publikováno v:
Journal of the American Chemical Society. 126(39)
A variety of spectroscopic and computational techniques have been used to examine the thermochromic transition previously reported for the oxidized state of Mn-dependent superoxide dismutase from E. coli in the presence of substrate analog azide (N(3
Publikováno v:
Journal of the American Chemical Society. 125(47)
Conformational changes occurring on the microsecond-millisecond time scale in basic pancreatic trypsin inhibitor (BPTI) are investigated using nuclear magnetic resonance spectroscopy. The rczz CPMG experiment (Wang, C.; Grey, M. J.; Palmer, A. G. J.
Publikováno v:
Journal of the American Chemical Society. 124(47)
Alkylation of N-nitrosourethane tetrabutylammonium salt (2-Bu(4)N) with four electrophiles (MeI, EtI, i-PrI, and PhCH(2)Br) was studied by (1)H NMR in CD(2)Cl(2) and CD(3)CN solutions. The ratio of the three regioisomers N-alkyl-N-nitrosourethane 3,