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Autor:
Avital-Shmilovici M; Department of Chemistry, The University of Chicago, Chicago, Illinois 60637, USA., Mandal K, Gates ZP, Phillips NB, Weiss MA, Kent SB
Publikováno v:
Journal of the American Chemical Society [J Am Chem Soc] 2013 Feb 27; Vol. 135 (8), pp. 3173-85. Date of Electronic Publication: 2013 Feb 08.
Autor:
Michal Avital-Shmilovici, Kalyaneswar Mandal, Nelson B. Phillips, Michael A. Weiss, Zachary P. Gates, Stephen B. H. Kent
Publikováno v:
Journal of the American Chemical Society. 135:3173-3185
Efficient total synthesis of insulin is important to enable the application of medicinal chemistry to the optimization of the properties of this important protein molecule. Recently we described "ester insulin"--a novel form of insulin in which the f